ube2wa ubiquitin conjugating enzyme E2 Wa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ube2waprovided by ZNC
Official Full Name: ubiquitin conjugating enzyme E2 Waprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050506-94
See related: Ensembl:ENSDARG00000044923 AllianceGenome:ZFIN:ZDB-GENE-050506-94
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ube2w; im:6905459; si:ch211-193n21.4
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in cellular protein metabolic process and cellular response to misfolded protein. Predicted to act upstream of or within DNA repair. Predicted to be active in nucleus. Orthologous to human UBE2W (ubiquitin conjugating enzyme E2 W). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (30193747..30199999, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (30210214..30216466, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cellular response to misfolded protein	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein quality control for misfolded or incompletely synthesized proteins	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable ubiquitin-conjugating enzyme E2 W-A

Names: E2 ubiquitin-conjugating enzyme W-A; N-terminal E2 ubiquitin-conjugating enzyme; probable ubiquitin-conjugating enzyme E2 W; ubiquitin carrier protein W; ubiquitin carrier protein W-A; ubiquitin-conjugating enzyme E2W (putative); ubiquitin-protein ligase W; ubiquitin-protein ligase W-A

NP_001116444.1

EC 2.3.2.23

EC 2.3.2.25

XP_021335984.1

EC 2.3.2.23

EC 2.3.2.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122972.1 → NP_001116444.1 probable ubiquitin-conjugating enzyme E2 W-A

See identical proteins and their annotated locations for NP_001116444.1

Status: VALIDATED

Source sequence(s)

BC095816, CT027743

UniProtKB/Swiss-Prot

B0V2U1, Q4VBH4

Related

ENSDARP00000108827.2, ENSDART00000130142.3

Conserved Domains (1) summary

pfam00179
Location:7 → 148

UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

30193747..30199999 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480309.1 → XP_021335984.1 probable ubiquitin-conjugating enzyme E2 W-A isoform X1

UniProtKB/TrEMBL

A0A8M9QEP1

Conserved Domains (1) summary

pfam00179
Location:12 → 126

UQ_con; Ubiquitin-conjugating enzyme