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    mmachc metabolism of cobalamin associated C [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 549685, updated on 5-Mar-2024

    Summary

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    Official Symbol
    mmachcprovided by Xenbase
    Official Full Name
    metabolism of cobalamin associated Cprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-963487
    See related
    Ensembl:ENSXETG00000003502
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Orthologs
    human mouse all
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    Genomic context

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    See mmachc in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (90390149..90395041, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 4 NC_030680.1 (73207035..73211884)

    Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member A1 (aldehyde reductase) Neighboring gene peroxiredoxin 1 Neighboring gene myosin-2 heavy chain, non muscle Neighboring gene uncharacterized XB5735880

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cobalamin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyanocobalamin reductase (cyanide-eliminating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyanocobalamin reductase (cyanide-eliminating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cobalamin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyanocobalamin reductase / alkylcobalamin dealkylase; methylmalonic aciduria and homocystinuria type C protein
    Names
    methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
    NP_001016931.1
    XP_012816600.2
    XP_012816601.2
    XP_012816602.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001016931.2 → NP_001016931.1  cyanocobalamin reductase / alkylcobalamin dealkylase

      Status: PROVISIONAL

      Source sequence(s)
      CR762179
      UniProtKB/TrEMBL
      A0A8J0PIL3
      Conserved Domains (1) summary
      pfam16690
      Location:1 → 177
      MMACHC; Methylmalonic aciduria and homocystinuria type C family

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      90390149..90395041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012961146.3 → XP_012816600.2  methylmalonic aciduria and homocystinuria type C protein isoform X1

      UniProtKB/TrEMBL
      A0A6I8Q1G4
      Related
      ENSXETP00000061265.2, ENSXETT00000063627.3
      Conserved Domains (1) summary
      pfam16690
      Location:19 → 233
      MMACHC; Methylmalonic aciduria and homocystinuria type C family

    2. XM_012961147.3 → XP_012816601.2  methylmalonic aciduria and homocystinuria type C protein isoform X2

      UniProtKB/TrEMBL
      A0A8J0SIR3
      Conserved Domains (1) summary
      pfam16690
      Location:2 → 208
      MMACHC; Methylmalonic aciduria and homocystinuria type C family

    3. XM_012961148.2 → XP_012816602.2  methylmalonic aciduria and homocystinuria type C protein isoform X2

      UniProtKB/TrEMBL
      A0A8J0SIR3
      Conserved Domains (1) summary
      pfam16690
      Location:2 → 208
      MMACHC; Methylmalonic aciduria and homocystinuria type C family
    Nucleotide Protein Strain
    Heading Accession and Version

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