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    Dnal4 dynein, axonemal, light chain 4 [ Mus musculus (house mouse) ]

    Gene ID: 54152, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Dnal4provided by MGI
    Official Full Name
    dynein, axonemal, light chain 4provided by MGI
    Primary source
    MGI:MGI:1859217
    See related
    Ensembl:ENSMUSG00000022420 AllianceGenome:MGI:1859217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dnalc4; D15Ertd424e
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and identical protein binding activity. Predicted to be involved in microtubule-based process. Predicted to be located in cilium; cytoplasm; and microtubule. Predicted to be part of dynein complex. Is expressed in central nervous system; heart ventricle; and retina. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to human DNAL4 (dynein axonemal light chain 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 61.0), whole brain E14.5 (RPKM 24.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 E1; 15 37.85 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79645654..79658649, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79761449..79774467, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Sad1 and UNC84 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E7390 Neighboring gene predicted gene 16576 Neighboring gene STARR-positive B cell enhancer ABC_E390 Neighboring gene predicted gene, 30977 Neighboring gene predicted gene, 57816 Neighboring gene neuronal pentraxin receptor Neighboring gene neuronal pentraxin chromo domain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal light chain 4
    Names
    dynein light chain 4, axonemal
    dynein, axon, light chain 4
    outer arm dynein light chain 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411918.1 → NP_001398847.1  dynein axonemal light chain 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC118227
      UniProtKB/Swiss-Prot
      O54793, Q3V233, Q99K65, Q9DCM4
      Related
      ENSMUSP00000154848.2, ENSMUST00000162713.9

    2. NM_001411919.1 → NP_001398848.1  dynein axonemal light chain 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC118227
      UniProtKB/TrEMBL
      A0A2R8VI05
      Related
      ENSMUSP00000155613.2, ENSMUST00000229644.2

    3. NM_017470.3 → NP_059498.2  dynein axonemal light chain 4 isoform 1

      See identical proteins and their annotated locations for NP_059498.2

      Status: VALIDATED

      Source sequence(s)
      AC118227
      Consensus CDS
      CCDS27650.1
      UniProtKB/Swiss-Prot
      O54793, Q3V233, Q99K65, Q9DCM4
      Related
      ENSMUSP00000023055.7, ENSMUST00000023055.8
      Conserved Domains (1) summary
      cd21453
      Location:21 → 103
      DLC-like_DNAL4; dynein light chain (DLC)-like domain found in axonemal dynein light chain 4 (DNAL4) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79645654..79658649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCM4.2 GenPept UniProtKB/Swiss-Prot:Q9DCM4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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