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    faim2a Fas apoptotic inhibitory molecule 2a [ Danio rerio (zebrafish) ]

    Gene ID: 541391, updated on 27-Mar-2024

    Summary

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    Official Symbol
    faim2aprovided by ZNC
    Official Full Name
    Fas apoptotic inhibitory molecule 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050320-88
    See related
    Ensembl:ENSDARG00000038784 AllianceGenome:ZFIN:ZDB-GENE-050320-88
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110143
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in female organism. Orthologous to human FAIM2 (Fas apoptotic inhibitory molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See faim2a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (32494212..32505170, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (32505865..32522260, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 member 2a Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene ATP-binding cassette, sub-family F (GCN20), member 2a Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination. Yan YL, et al. Genetics, 2019 Oct. PMID 31399485, Free PMC Article
    2. Gene duplication, conservation, and divergence of activating transcription factor 5 gene in zebrafish. Zhu H, et al. J Exp Zool B Mol Dev Evol, 2022 Jul. PMID 35226401
    3. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fas apoptotic inhibitory molecule 2; protein lifeguard 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013518.1 → NP_001013536.1  protein lifeguard 2a

      See identical proteins and their annotated locations for NP_001013536.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091446
      UniProtKB/TrEMBL
      Q5BJK5
      Related
      ENSDARP00000056638.4, ENSDART00000056639.6
      Conserved Domains (1) summary
      cd10428
      Location:83 → 303
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      32494212..32505170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163497.4 → XP_005163554.1  fas apoptotic inhibitory molecule 2 isoform X1

      See identical proteins and their annotated locations for XP_005163554.1

      UniProtKB/TrEMBL
      A0A8M2BAP7, F1QZ65
      Conserved Domains (1) summary
      cd10428
      Location:83 → 303
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    2. XM_009298617.3 → XP_009296892.1  fas apoptotic inhibitory molecule 2 isoform X1

      See identical proteins and their annotated locations for XP_009296892.1

      UniProtKB/TrEMBL
      A0A8M2BAP7, F1QZ65
      Related
      ENSDARP00000154611.1, ENSDART00000181309.1
      Conserved Domains (1) summary
      cd10428
      Location:83 → 303
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
    Nucleotide Protein Strain
    Heading Accession and Version

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