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    mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 493369, updated on 5-Mar-2024

    Summary

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    Official Symbol
    mthfd1provided by Xenbase
    Official Full Name
    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetaseprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-992132
    See related
    Ensembl:ENSXETG00000022511
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 8
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 8 NC_030684.2 (101038003..101075868, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 8 NC_030684.1 (80751841..80791442, complement)

    Chromosome 8 - NC_030684.2Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene A-kinase anchor protein 5 Neighboring gene coiled-coil domain-containing protein 170 Neighboring gene uncharacterized LOC116406902 Neighboring gene estrogen receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC79474

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables formate-tetrahydrofolate ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methenyltetrahydrofolate cyclohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-1-tetrahydrofolate synthase, cytoplasmic
    NP_001008007.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008006.1 → NP_001008007.1  C-1-tetrahydrofolate synthase, cytoplasmic

      See identical proteins and their annotated locations for NP_001008007.1

      Status: PROVISIONAL

      Source sequence(s)
      BC080885
      UniProtKB/TrEMBL
      A0A6I8RU45, Q66JJ9
      Related
      ENSXETP00000088488.2, ENSXETT00000088510.2
      Conserved Domains (4) summary
      cd01080
      Location:119 → 291
      NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:308 → 934
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:5 → 295
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:5 → 124
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      101038003..101075868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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