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    smad3 SMAD family member 3 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 493272, updated on 5-Mar-2024

    Summary

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    Official Symbol
    smad3provided by Xenbase
    Official Full Name
    SMAD family member 3provided by Xenbase
    Primary source
    Xenbase:XB-GENE-481992
    See related
    Ensembl:ENSXETG00000007804
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    Xmad3; madh3; XSmad3; XenMLP; jv15-2; hspc193; hst17436
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (117365966..117426998)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 3 NC_030679.1 (116708039..116789519, complement)

    Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene zwilch kinetochore protein Neighboring gene lactase like Neighboring gene SMAD family member 6 Neighboring gene alpha and gamma adaptin binding protein Neighboring gene IQ motif containing H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear accumulation of Smad complexes occurs only after the midblastula transition in Xenopus. Saka Y, et al. Development, 2007 Dec. PMID 17959720, Free PMC Article
    2. Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides. Rana AA, et al. PLoS Genet, 2006 Nov 17. PMID 17112317, Free PMC Article
    3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Smad2-Smad2 and Smad2-Smad4 complexes accumulate rapidly in the nuclei of responding cells following Activin treatment.
      Title: Nuclear accumulation of Smad complexes occurs only after the midblastula transition in Xenopus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC89865

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mothers against decapentaplegic homolog 3
    Names
    mothers against DPP homolog 3
    smad 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008436.2 → NP_001008436.1  mothers against decapentaplegic homolog 3

      See identical proteins and their annotated locations for NP_001008436.1

      Status: PROVISIONAL

      Source sequence(s)
      BC080156
      UniProtKB/TrEMBL
      A0A6I8PPP3, Q68EP5
      Related
      ENSXETP00000064162.2, ENSXETT00000101227.2
      Conserved Domains (2) summary
      cd10491
      Location:8 → 132
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:224 → 414
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      117365966..117426998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018092042.2 → XP_017947531.1  mothers against decapentaplegic homolog 3 isoform X1

      UniProtKB/TrEMBL
      A0A6I8QWM5, A0A8J0T288
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.