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    aPKC atypical protein kinase C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47594, updated on 14-Sep-2019

    Summary

    Official Symbol
    aPKCprovided by FlyBase
    Official Full Name
    atypical protein kinase Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261854
    Locus tag
    Dmel_CG42783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    a-PKC; alphaPKCzeta; apkc; aPkc; aPKC zeta; aPKC-zeta; aPKCzeta; CG10261; CG30475; CG42783; dapkc; daPKC; DaPKC; Dmel\CG42783; i; l(2)k06403; pkc-3; PKCl; PKCzeta; psu
    Old locus tag
    CG30475; Dmel_CG10261; Dmel_CG30475

    Genomic context

    See aPKC in Genome Data Viewer
    Location:
    51D5-51D5; 2-73 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14944458..14962969, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10831963..10850474, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Alkyldihydroxyacetonephosphate synthase Neighboring gene uncharacterized protein Neighboring gene Lap1 Neighboring gene uncharacterized protein Neighboring gene caskin Neighboring gene transfer RNA:Leucine-AAG 1-1 Neighboring gene parcas

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    myosin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apical protein localization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    asymmetric neuroblast division IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    asymmetric protein localization involved in cell fate determination IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    branching involved in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell junction assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    compound eye retinal cell programmed cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epithelial cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    epithelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of epithelial cell apical/basal polarity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    establishment of epithelial cell planar polarity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    establishment of epithelial cell planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of cell polarity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of epithelial cell apical/basal polarity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    establishment or maintenance of neuroblast polarity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    establishment or maintenance of neuroblast polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of neuroblast polarity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    establishment or maintenance of polarity of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of polarity of embryonic epithelium NAS
    Non-traceable Author Statement
    more info
    PubMed 
    establishment or maintenance of polarity of follicular epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exocyst localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germarium-derived oocyte fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    morphogenesis of a polarized epithelium TAS
    Traceable Author Statement
    more info
    PubMed 
    oocyte anterior/posterior axis specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of polarized epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    terminal branching, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    zonula adherens assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    apical cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical cortex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    apical plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex TAS
    Traceable Author Statement
    more info
    PubMed 
    subapical complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    atypical protein kinase C
    Names
    CG42783-PA
    CG42783-PB
    CG42783-PC
    CG42783-PD
    CG42783-PE
    CG42783-PF
    CG42783-PG
    CG42783-PI
    CG42783-PJ
    CG42783-PK
    CG42783-PL
    CG42783-PM
    aPKC-PA
    aPKC-PB
    aPKC-PC
    aPKC-PD
    aPKC-PE
    aPKC-PF
    aPKC-PG
    aPKC-PI
    aPKC-PJ
    aPKC-PK
    aPKC-PL
    aPKC-PM
    atypical PKC
    atypical protein kinase
    atypical-Protein kinase C
    pschur
    NP_001036541.1
    NP_001036542.1
    NP_001036543.1
    NP_001036544.1
    NP_001036545.1
    NP_001188939.1
    NP_001188941.1
    NP_001260984.1
    NP_001260985.1
    NP_001260986.1
    NP_001260987.1
    NP_524892.2

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14944458..14962969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080153.5NP_524892.2  atypical protein kinase C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524892.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z9X0
      Related
      FBpp0292491, FBtr0303434
      Conserved Domains (4) summary
      cd06404
      Location:31113
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      smart00220
      Location:264532
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05588
      Location:268595
      STKc_aPKC; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C
      pfam00130
      Location:146198
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    2. NM_001043080.3NP_001036545.1  atypical protein kinase C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036545.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z9X0
      Related
      FBpp0292488, FBtr0303431
      Conserved Domains (4) summary
      cd06404
      Location:31113
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      smart00220
      Location:264532
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05588
      Location:268597
      STKc_aPKC; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C
      pfam00130
      Location:146198
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    3. NM_001274055.1NP_001260984.1  atypical protein kinase C, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260984.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG15
      Related
      FBpp0302921, FBtr0329887
      Conserved Domains (3) summary
      smart00220
      Location:616884
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05588
      Location:620947
      STKc_aPKC; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C
      pfam00130
      Location:498550
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    4. NM_001274056.2NP_001260985.1  atypical protein kinase C, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260985.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFQ6
      Related
      FBpp0302922, FBtr0329888
      Conserved Domains (3) summary
      smart00220
      Location:177445
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05588
      Location:181508
      STKc_aPKC; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C
      pfam00130
      Location:59111
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    5. NM_001274058.2NP_001260987.1  atypical protein kinase C, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260987.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEQ8
      Related
      FBpp0302924, FBtr0329890
      Conserved Domains (3) summary
      smart00220
      Location:161429
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05588
      Location:165492
      STKc_aPKC; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C
      pfam00130
      Location:4395
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    6. NM_001274057.2NP_001260986.1  atypical protein kinase C, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260986.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEV2
      Related
      FBpp0302923, FBtr0329889
      Conserved Domains (3) summary
      smart00220
      Location:161429
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05588
      Location:165492
      STKc_aPKC; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C
      pfam00130
      Location:4395
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    7. NM_001043077.3NP_001036542.1  atypical protein kinase C, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036542.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z9X0
      Related
      FBpp0292490, FBtr0303433
      Conserved Domains (3) summary
      smart00220
      Location:161429
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05588
      Location:165492
      STKc_aPKC; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C
      pfam00130
      Location:4395
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    8. NM_001043076.3NP_001036541.1  atypical protein kinase C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036541.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z9X0
      Related
      FBpp0292487, FBtr0303430
      Conserved Domains (4) summary
      cd06404
      Location:31113
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      smart00220
      Location:264532
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05588
      Location:268595
      STKc_aPKC; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C
      pfam00130
      Location:146198
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    9. NM_001202010.4NP_001188939.1  atypical protein kinase C, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188939.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD78
      Related
      FBpp0292492, FBtr0303435
      Conserved Domains (3) summary
      smart00220
      Location:609877
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05588
      Location:613940
      STKc_aPKC; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C
      pfam00130
      Location:491543
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    10. NM_001043078.2NP_001036543.1  atypical protein kinase C, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036543.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z9X0
      Related
      FBpp0292489, FBtr0303432
      Conserved Domains (3) summary
      smart00220
      Location:182450
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05588
      Location:186513
      STKc_aPKC; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C
      pfam00130
      Location:64116
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    11. NM_001043079.2NP_001036544.1  atypical protein kinase C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036544.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z9X0
      Related
      FBpp0292486, FBtr0303429
      Conserved Domains (3) summary
      smart00220
      Location:182450
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05588
      Location:186515
      STKc_aPKC; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C
      pfam00130
      Location:64116
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    12. NM_001202012.2NP_001188941.1  atypical protein kinase C, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188941.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD26
      Related
      FBpp0292494, FBtr0303437
      Conserved Domains (3) summary
      smart00220
      Location:182450
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05588
      Location:186498
      STKc_aPKC; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C
      pfam00130
      Location:64116
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
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