cv crossveinless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cvprovided by FlyBase
Official Full Name: crossveinlessprovided by FlyBase
Primary source: FLYBASE:FBgn0000394
Locus tag: Dmel_CG12410
See related: AllianceGenome:FB:FBgn0000394
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12410; Cv; cv-1; Dmel\CG12410; tsg2; Tsg2
Summary: Enables BMP binding activity. Involved in positive regulation of muscle organ development; regulation of BMP signaling pathway; and regulation of imaginal disc-derived wing vein specification. Located in extracellular space. Is expressed in organism; presumptive wing vein; pupal cuticle; tracheal pit; and wing disc. Orthologous to human TWSG1 (twisted gastrulation BMP signaling modulator 1). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5690002..5693084)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5584035..5587117)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

an upstream regulatory region of cv is directly responsive to the basic, helix-loop-helix-PAS domain factors Trachealess (Trh) and Tango (Tgo), that function to specify tracheal fate.
Title: Crossveinless is a direct transcriptional target of Trachealess and Tango in Drosophila tracheal precursor cells.
Sog and Cv promote BMP signaling by transporting a BMP heterodimer from the longitudinal veins into the crossvein regions.
Title: The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing.
crossveinless represents a subgroup of the Twisted gastrulation-like bone morphogenetic protein-modulating proteins
Title: crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables BMP binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

Names: CG12410-PA; CG12410-PB; CG12410-PC; crossvein; cv-PA; cv-PB; cv-PC; twisted gastrulation 2

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