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    myo myoglianin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43811, updated on 11-Apr-2024

    Summary

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    Official Symbol
    myoprovided by FlyBase
    Official Full Name
    myoglianinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026199
    Locus tag
    Dmel_CG1838
    See related
    AllianceGenome:FB:FBgn0026199
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD02307; CG1838; Dmel\CG1838; DmMyo; myg; Myo; MYO; Myoglianin
    Summary
    Enables activin receptor binding activity and receptor ligand activity. Involved in several processes, including activin receptor signaling pathway; animal organ development; and positive regulation of SMAD protein signal transduction. Acts upstream of with a positive effect on determination of adult lifespan. Located in nucleus. Is expressed in embryonic/larval muscle cell; germline cell; glial cell; glioblast; and heart primordium. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy. Orthologous to human GDF11 (growth differentiation factor 11) and MSTN (myostatin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    102D4-102D4; 4-0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (690686..696055, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (711312..716681, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene SLo interacting protein 1 Neighboring gene uncharacterized protein Neighboring gene eyeless Neighboring gene bent

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complex roles of myoglianin in regulating adult performance and lifespan. Augustin H, et al. Fly (Austin), 2017 Oct 2. PMID 28837401, Free PMC Article
    2. Heterozygous loss-of-function variants significantly expand the phenotypes associated with loss of GDF11. Ravenscroft TA, et al. Genet Med, 2021 Oct. PMID 34113007, Free PMC Article
    3. Glial Derived TGF-β Instructs Axon Midline Stopping. Marmor-Kollet N, et al. Front Mol Neurosci, 2019. PMID 31611773, Free PMC Article
    4. Mechanical coordination is sufficient to promote tissue replacement during metamorphosis in Drosophila. Prat-Rojo C, et al. EMBO J, 2020 Feb 3. PMID 31858605, Free PMC Article
    5. Intertissue control of the nucleolus via a myokine-dependent longevity pathway. Demontis F, et al. Cell Rep, 2014 Jun 12. PMID 24882005, Free PMC Article

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plum modulates Myoglianin and regulates synaptic function in D. melanogaster.
      Title: Plum modulates Myoglianin and regulates synaptic function in D. melanogaster.
    2. Muscle-derived Myoglianin regulates Drosophila imaginal disc growth.
      Title: Muscle-derived Myoglianin regulates Drosophila imaginal disc growth.
    3. Myoglianin (MYO), the Drosophila homolog of myostatin and GDF11, regulates not only body weight and muscle size, but also inhibits neuromuscular synapse strength and composition in a Smad2-dependent manner.
      Title: Myostatin-like proteins regulate synaptic function and neuronal morphology.
    4. BEAF and GAF are positive regulators of the chromatin domain boundary that separates myoglianin and eyeless genes.
      Title: A BEAF dependent chromatin domain boundary separates myoglianin and eyeless genes of Drosophila melanogaster.
    5. Results suggest that Wishful thinking binds multiple ligands to activate both bone morphogenetic protein and transforming growth factor-beta-like signaling pathways, and may mediate myoglianin-dependent signals in the nervous system.
      Title: The Drosophila type II receptor, Wishful thinking, binds BMP and myoglianin to activate multiple TGFbeta family signaling pathways.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables activin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in R8 cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in activin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in activin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in activin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of imaginal disc-derived wing size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synapse structure or activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    myoglianin
    Names
    CG1838-PA
    CG1838-PC
    CG1838-PD
    DmMyoglianin
    myo-PA
    myo-PC
    myo-PD
    myoglianine

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      690686..696055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166788.2 → NP_726606.1  myoglianin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726606.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4F4, Q9XZ62
      Related
      FBpp0088164
      Conserved Domains (1) summary
      pfam00019
      Location:506 → 597
      TGF_beta; Transforming growth factor beta like domain

    2. NM_166786.2 → NP_726604.1  myoglianin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726604.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4F4, Q9XZ62
      Related
      FBpp0088161
      Conserved Domains (1) summary
      pfam00019
      Location:506 → 597
      TGF_beta; Transforming growth factor beta like domain

    3. NM_166787.2 → NP_726605.1  myoglianin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726605.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4F4, Q9XZ62
      Related
      FBpp0088163
      Conserved Domains (1) summary
      pfam00019
      Location:506 → 597
      TGF_beta; Transforming growth factor beta like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V4F4 Q9V4F4
    Q9XZ62 Q9XZ62

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