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    shps sheepish [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42892, updated on 27-Mar-2024

    Summary

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    Official Symbol
    shpsprovided by FlyBase
    Official Full Name
    sheepishprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286199
    Locus tag
    Dmel_CG13611
    See related
    AllianceGenome:FB:FBgn0286199
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13611; Dmel\CG13611
    Summary
    Predicted to enable flavin adenine dinucleotide binding activity and primary amine oxidase activity. Predicted to be active in mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in Alzheimer's disease; Brunner Syndrome; alcohol use disorder; autism spectrum disorder; and panic disorder. Orthologous to human IL4I1 (interleukin 4 induced 1) and MAOA (monoamine oxidase A). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    95F8-95F9; 3-84 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24279572..24281576)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20105294..20107298)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Organic cation transporter 2 Neighboring gene Organic cation transporter Neighboring gene long non-coding RNA:CR45662 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Severe Fertility Effects of sheepish Sperm Caused by Failure To Enter Female Sperm Storage Organs in Drosophila melanogaster. Tomaru M, et al. G3 (Bethesda), 2018 Jan 4. PMID 29158336, Free PMC Article
    2. α-amanitin resistance in Drosophila melanogaster: A genome-wide association approach. Mitchell CL, et al. PLoS One, 2017. PMID 28241077, Free PMC Article
    3. Dissecting the lean, mean, breeding machine. Nurminsky DI. Fly (Austin), 2007 Mar-Apr. PMID 19378459
    4. Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. Doggett K, et al. Dev Biol, 2011 Jul 15. PMID 21570388, Free PMC Article
    5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Severe fertility effects of sheepish-deficient sperm caused by failure to enter female sperm storage organs in Drosophila melanogaster.
      Title: Severe Fertility Effects of sheepish Sperm Caused by Failure To Enter Female Sperm Storage Organs in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monoamine oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sheepish
    Names
    CG13611-PA
    shps-PA
    NP_651239.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24279572..24281576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142982.3 → NP_651239.1  sheepish [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651239.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCA1
      Related
      FBpp0083984
      Conserved Domains (2) summary
      pfam01593
      Location:21 → 409
      Amino_oxidase; Flavin containing amine oxidoreductase
      cl21454
      Location:11 → 53
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCA1 Q9VCA1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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