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    cd cardinal [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42681, updated on 11-Apr-2024

    Summary

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    Official Symbol
    cdprovided by FlyBase
    Official Full Name
    cardinalprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263986
    Locus tag
    Dmel_CG6969
    See related
    AllianceGenome:FB:FBgn0263986
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6969; Dmel\CG6969; HPX6; PHS
    Summary
    Predicted to enable peroxidase activity. Involved in several processes, including kynurenine metabolic process; negative regulation of gene silencing by RNA; and ommochrome biosynthetic process. Located in lysosome. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in congenital hypothyroidism; glomerulonephritis; and thyroid dyshormonogenesis 2A. Orthologous to human TPO (thyroid peroxidase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    94C1-94C1; 3-76 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22694959..22697990)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18520681..18523712)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene wolfram syndrome 1 Neighboring gene Nucleoporin 133kD Neighboring gene Cytochrome P450 6d4 Neighboring gene Crustacean cardioactive peptide Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 3-Hydroxykynurenine as a Potential Ligand for Hsp70 Proteins and Its Effects on Drosophila Memory After Heat Shock. Zhuravlev AV, et al. Mol Neurobiol, 2022 Mar. PMID 35029786
    2. 3-Hydroxykynurenine in Regulation of Drosophila Behavior: The Novel Mechanisms for Cardinal Phenotype Manifestations. Zhuravlev AV, et al. Front Physiol, 2020. PMID 32848886, Free PMC Article
    3. Enzymatic and non-enzymatic pathways of kynurenines' dimerization: the molecular factors for oxidative stress development. Zhuravlev AV, et al. PLoS Comput Biol, 2018 Dec. PMID 30532237, Free PMC Article
    4. FURTHER GENETIC STUDIES OF THE SOUTH AMHERST POPULATION OF DROSOPHILA MELANOGASTER. Ives PT. Evolution, 1970 Sep. PMID 28562987
    5. cd(1) Mutation in Drosophila Affects Phenoxazinone Synthase Catalytic Site and Impairs Long-Term Memory. Zhuravlev AV, et al. Int J Mol Sci, 2022 Oct 15. PMID 36293213, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in kynurenine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ommochrome biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cardinal
    Names
    CG6969-PA
    cd-PA
    phenoxazinone synthase
    phenoxazinone synthetase
    NP_651081.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22694959..22697990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142824.3 → NP_651081.1  cardinal [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651081.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCW2
      Related
      FBpp0083696
      Conserved Domains (2) summary
      cd09823
      Location:364 → 750
      peroxinectin_like; peroxinectin_like animal heme peroxidases
      pfam03098
      Location:218 → 755
      An_peroxidase; Animal haem peroxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCW2 Q9VCW2

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