MEST mesoderm specific transcript [Homo sapiens (human)] - Gene

Summary

Official Symbol: MESTprovided by HGNC
Official Full Name: mesoderm specific transcriptprovided by HGNC
Primary source: HGNC:HGNC:7028
See related: Ensembl:ENSG00000106484 MIM:601029; AllianceGenome:HGNC:7028
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PEG1
Summary: This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]
Expression: Biased expression in placenta (RPKM 292.2), fat (RPKM 48.4) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q32.2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (130486175..130506465)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (131799896..131820184)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (130126016..130146306)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alpha1,3-fucosylation of MEST promotes invasion potential of cytotrophoblast cells by activating translation initiation.
Title: α1,3-fucosylation of MEST promotes invasion potential of cytotrophoblast cells by activating translation initiation.
Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis.
Title: Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis.
MiR-29c-3p represses gastric cancer development via modulating MEST.
Title: MiR-29c-3p represses gastric cancer development via modulating MEST.
Human umbilical cord blood mesenchymal stem cells-derived exosomal microRNA-503-3p inhibits progression of human endometrial cancer cells through downregulating MEST.
Title: Human umbilical cord blood mesenchymal stem cells-derived exosomal microRNA-503-3p inhibits progression of human endometrial cancer cells through downregulating MEST.
Increased co-expression of MEST and BRCA1 is associated with worse prognosis and immune infiltration in ovarian cancer.
Title: Increased co-expression of MEST and BRCA1 is associated with worse prognosis and immune infiltration in ovarian cancer.
miR-145-5p Modulates Gefitinib Resistance by Targeting NRAS and MEST in Non-Small Cell Lung Cancer.
Title: miR-145-5p Modulates Gefitinib Resistance by Targeting NRAS and MEST in Non-Small Cell Lung Cancer.
MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-kappaB signaling.
Title: MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-κB signaling.
Hypermethylation of Mest promoter causes aberrant Wnt signaling in patients with Alzheimer's disease.
Title: Hypermethylation of Mest promoter causes aberrant Wnt signaling in patients with Alzheimer's disease.
The effect of folic acid deficiency on Mest/Peg1 in neural tube defects.
Title: The effect of folic acid deficiency on Mest/Peg1 in neural tube defects.
The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis.
Title: The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2012-04-04) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2012-04-04) ClinGen Genome Curation Page

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH12524 (e-PCR)
- UniSTS:16028

GDB:3755019 (e-PCR)
- UniSTS:39581

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mesoderm development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed

General protein information

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Preferred Names: mesoderm-specific transcript homolog protein

Names: paternally-expressed gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009226.1 RefSeqGene

Range

10881..25261

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1033

mRNA and Protein(s)

NM_001253900.1 → NP_001240829.1 mesoderm-specific transcript homolog protein isoform c

See identical proteins and their annotated locations for NP_001240829.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AA728839, AK298984, BC090049, CN425918, DC367784

UniProtKB/TrEMBL

B4DQW6

Conserved Domains (2) summary

pfam00561
Location:58 → 307

Abhydrolase_1; alpha/beta hydrolase fold

cl21494
Location:56 → 138

Abhydrolase; alpha/beta hydrolases
NM_001253901.1 → NP_001240830.1 mesoderm-specific transcript homolog protein isoform d precursor

See identical proteins and their annotated locations for NP_001240830.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks an exon in the coding region and uses a downstream, in-frame start codon, compared to variant 1. Variants 5 and 6 encode the same isoform (d), which is shorter than isoform a.

Source sequence(s)

AA728839, BC090049, BG831799

Consensus CDS

CCDS59081.1

UniProtKB/TrEMBL

C9JW74

Related

ENSP00000408933.2, ENST00000416162.7

Conserved Domains (1) summary

COG0596
Location:38 → 278

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
NM_001253902.1 → NP_001240831.1 mesoderm-specific transcript homolog protein isoform d precursor

See identical proteins and their annotated locations for NP_001240831.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, lacks an exon in the coding region and uses a downstream, in-frame start codon, compared to variant 1. Variants 5 and 6 encode the same isoform (d), which is shorter than isoform a.

Source sequence(s)

AA728839, BC090049, DA487705

Consensus CDS

CCDS59081.1

UniProtKB/TrEMBL

C9JW74

Related

ENSP00000409505.2, ENST00000427521.6

Conserved Domains (1) summary

COG0596
Location:38 → 278

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
NM_002402.4 → NP_002393.2 mesoderm-specific transcript homolog protein isoform a

See identical proteins and their annotated locations for NP_002393.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). This isoform (a) is imprinted and expressed only from the paternal allele.

Source sequence(s)

AA728839, AC007938, BC011908, BC090049, DC367784

Consensus CDS

CCDS5822.1

UniProtKB/Swiss-Prot

B2R6S1, O14973, O15007, Q5EB52, Q6AI49, Q92571

UniProtKB/TrEMBL

C9JW74

Related

ENSP00000223215.4, ENST00000223215.10

Conserved Domains (1) summary

COG0596
Location:47 → 321

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
NM_177524.2 → NP_803490.1 mesoderm-specific transcript homolog protein isoform b precursor

See identical proteins and their annotated locations for NP_803490.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (b), which has a shorter N-terminus compared to isoform a. This isoform (b) is biallelically expressed.

Source sequence(s)

AA728839, AK098397, BC090049, BG831799

Consensus CDS

CCDS5823.1

UniProtKB/TrEMBL

A4D1L9, C9JW74

Related

ENSP00000342749.4, ENST00000341441.9

Conserved Domains (1) summary

COG0596
Location:38 → 312

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
NM_177525.2 → NP_803491.1 mesoderm-specific transcript homolog protein isoform b precursor

See identical proteins and their annotated locations for NP_803491.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (b), which has a shorter N-terminus compared to isoform a. This isoform (b) is biallelically expressed.

Source sequence(s)

AA728839, AU118070, BC090049, DB454206

Consensus CDS

CCDS5823.1

UniProtKB/TrEMBL

A4D1L9, C9JW74

Related

ENSP00000376884.1, ENST00000393187.5

Conserved Domains (1) summary

COG0596
Location:38 → 312

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

130486175..130506465

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011516222.3 → XP_011514524.1 mesoderm-specific transcript homolog protein isoform X2

UniProtKB/TrEMBL

C9JW74

Conserved Domains (1) summary

COG0596
Location:47 → 287

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
XM_017012218.3 → XP_016867707.1 mesoderm-specific transcript homolog protein isoform X1

UniProtKB/TrEMBL

A4D1L9, C9JW74

Conserved Domains (1) summary

COG0596
Location:38 → 312

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

131799896..131820184

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054358254.1 → XP_054214229.1 mesoderm-specific transcript homolog protein isoform X2
XM_054358253.1 → XP_054214228.1 mesoderm-specific transcript homolog protein isoform X1

UniProtKB/TrEMBL

A4D1L9