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    fru fruitless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42226, updated on 4-Apr-2024

    Summary

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    Official Symbol
    fruprovided by FlyBase
    Official Full Name
    fruitlessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004652
    Locus tag
    Dmel_CG14307
    See related
    AllianceGenome:FB:FBgn0004652
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BTB-VI; BtbVI; CG14307; cg7688; CG7688; cg7689; CG7689; CG7690; CT22773; Dmel\CG14307; Dmfru; Fru; FRU; FRU-PI; fruC; FruM; fry; fty; ms(3)06411; sat
    Summary
    Predicted to enable DNA-binding transcription factor activity. Involved in several processes, including aggressive behavior; mating behavior; and neuron development. Predicted to be active in nucleus. Is expressed in several structures, including adult; central nervous system; chemosensory system; imaginal disc; and reproductive system. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    91A6-91B3; 3-64 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18414273..18545586, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14239995..14371308, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hemotin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutually exclusive expression of sex-specific and non-sex-specific fruitless gene products in the Drosophila central nervous system. Sato K, et al. Gene Expr Patterns, 2022 Mar. PMID 35124238
    2. Drosophila sechellia: A Genetic Model for Behavioral Evolution and Neuroecology. Auer TO, et al. Annu Rev Genet, 2021 Nov 23. PMID 34530638
    3. Generation and characterization of fruitless P1 promoter mutant in Drosophila melanogaster. Neville MC, et al. J Neurogenet, 2021 Sep. PMID 34338589, Free PMC Article
    4. A non-coding indel polymorphism in the fruitless gene of Drosophila melanogaster exhibits antagonistically pleiotropic fitness effects. Jardine MD, et al. Proc Biol Sci, 2021 May 12. PMID 33975471, Free PMC Article
    5. Fruitless decommissions regulatory elements to implement cell-type-specific neuronal masculinization. Brovkina MV, et al. PLoS Genet, 2021 Feb. PMID 33600447, Free PMC Article

    See all (490) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of fruitless in specifying courtship behaviors across divergent Drosophila species.
      Title: The role of fruitless in specifying courtship behaviors across divergent Drosophila species.
    2. Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4.
      Title: Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4.
    3. From fruitless to sex: On the generation and diversification of an innate behavior.
      Title: From fruitless to sex: On the generation and diversification of an innate behavior.
    4. fruitless tunes functional flexibility of courtship circuitry during development.
      Title: fruitless tunes functional flexibility of courtship circuitry during development.
    5. Generation and characterization of fruitless P1 promoter mutant in Drosophila melanogaster.
      Title: Generation and characterization of fruitless P1 promoter mutant in Drosophila melanogaster.
    6. Analysis of cell-type-specific chromatin modifications and gene expression in Drosophila neurons that direct reproductive behavior.
      Title: Analysis of cell-type-specific chromatin modifications and gene expression in Drosophila neurons that direct reproductive behavior.
    7. Fruitless decommissions regulatory elements to implement cell-type-specific neuronal masculinization.
      Title: Fruitless decommissions regulatory elements to implement cell-type-specific neuronal masculinization.
    8. Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons.
      Title: Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons.
    9. Layered roles of fruitless isoforms in specification and function of male aggression-promoting neurons in Drosophila.
      Title: Layered roles of fruitless isoforms in specification and function of male aggression-promoting neurons in Drosophila.
    10. Drosulfakinin (DSKM) and fruitless (fruM)-expressing neurons inhibit male courtship.
      Title: Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila.
    Submit: New GeneRIF Correction See all GeneRIFs (50)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c18465625-18465569 mobile_element_type = transposon:Doc3{}5636

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon midline choice point recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in central nervous system neuron development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in copulation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in copulation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in male courtship behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in male courtship behavior, orientation prior to leg tapping and wing vibration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in male courtship behavior, tapping to detect pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior, veined wing extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior, veined wing generated song production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior, veined wing generated song production TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in male courtship behavior, veined wing vibration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male sex differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mating behavior, sex discrimination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mating behavior, sex discrimination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mating behavior, sex discrimination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex determination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fruitless
    Names
    BTB-protein-VI
    CG14307-PA
    CG14307-PB
    CG14307-PC
    CG14307-PD
    CG14307-PE
    CG14307-PF
    CG14307-PG
    CG14307-PH
    CG14307-PI
    CG14307-PJ
    CG14307-PK
    CG14307-PL
    CG14307-PM
    CG14307-PN
    CG14307-PO
    fru-PA
    fru-PB
    fru-PC
    fru-PD
    fru-PE
    fru-PF
    fru-PG
    fru-PH
    fru-PI
    fru-PJ
    fru-PK
    fru-PL
    fru-PM
    fru-PN
    fru-PO
    fru-satori
    fruity
    satori

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18414273..18545586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079673.3 → NP_524397.2  fruitless, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524397.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IN81
      Related
      FBpp0083064
      Conserved Domains (5) summary
      smart00225
      Location:31 → 115
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00614
      Location:643 → 680
      ZnF_BED; BED zinc finger
      sd00017
      Location:632 → 649
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:20 → 115
      BTB; BTB/POZ domain
      cl19237
      Location:615 → 666
      DUF45; Protein of unknown function DUF45

    2. NM_169816.2 → NP_732344.1  fruitless, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732344.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IN81
      Related
      FBpp0083061
      Conserved Domains (3) summary
      smart00614
      Location:744 → 781
      ZnF_BED; BED zinc finger
      sd00017
      Location:733 → 750
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18315
      Location:130 → 213
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

    3. NM_169817.2 → NP_732345.1  fruitless, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732345.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IN81
      Related
      FBpp0083065
      Conserved Domains (2) summary
      sd00019
      Location:638 → 655
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18315
      Location:130 → 213
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

    4. NM_169818.2 → NP_732346.1  fruitless, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732346.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IN81
      Related
      FBpp0083060
      Conserved Domains (3) summary
      smart00225
      Location:31 → 115
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:561 → 577
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:20 → 115
      BTB; BTB/POZ domain

    5. NM_001275783.1 → NP_001262712.1  fruitless, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG97
      Conserved Domains (3) summary
      smart00225
      Location:31 → 115
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:537 → 554
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:20 → 115
      BTB; BTB/POZ domain

    6. NM_206514.2 → NP_996236.1  fruitless, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996236.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IN81
      Conserved Domains (3) summary
      smart00225
      Location:41 → 125
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:571 → 587
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:30 → 125
      BTB; BTB/POZ domain

    7. NM_169819.2 → NP_732347.1  fruitless, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732347.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V334, O44708, P91618, P91619, Q24004, Q29QE0, Q7KSD2, Q7KSD5, Q7KSD6, Q8IN80, Q8IN81, Q8IN82, Q8IN83, Q8IS35, Q8IS36, Q9GU18, Q9GU19, Q9GU20, Q9GU21, Q9GU22, Q9VE64, Q9VE65, Q9VE66, Q9VE67
      Related
      FBpp0083063
      Conserved Domains (3) summary
      smart00225
      Location:132 → 216
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:896 → 913
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:121 → 216
      BTB; BTB/POZ domain

    8. NM_001170177.2 → NP_001163648.1  fruitless, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163648.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIP5
      Conserved Domains (3) summary
      smart00225
      Location:137 → 221
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:901 → 918
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:126 → 221
      BTB; BTB/POZ domain

    9. NM_169820.2 → NP_732348.1  fruitless, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732348.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IN81
      Related
      FBpp0083062
      Conserved Domains (3) summary
      smart00225
      Location:31 → 115
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:795 → 812
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:20 → 115
      BTB; BTB/POZ domain

    10. NM_206516.2 → NP_996238.1  fruitless, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996238.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IN81
      Conserved Domains (3) summary
      smart00225
      Location:47 → 131
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:811 → 828
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:36 → 131
      BTB; BTB/POZ domain

    11. NM_206515.2 → NP_996237.1  fruitless, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996237.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IN81
      Conserved Domains (3) summary
      smart00225
      Location:83 → 167
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:847 → 864
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:72 → 167
      BTB; BTB/POZ domain

    12. NM_206513.2 → NP_996235.1  fruitless, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996235.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IN81
      Conserved Domains (3) summary
      smart00225
      Location:31 → 115
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:795 → 812
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:20 → 115
      BTB; BTB/POZ domain

    13. NM_206512.2 → NP_996234.1  fruitless, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996234.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IN81
      Conserved Domains (3) summary
      smart00225
      Location:31 → 115
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:795 → 812
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:20 → 115
      BTB; BTB/POZ domain

    14. NM_169821.2 → NP_732349.1  fruitless, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732349.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IN81
      Related
      FBpp0083066
      Conserved Domains (2) summary
      smart00225
      Location:31 → 115
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:20 → 115
      BTB; BTB/POZ domain

    15. NM_169822.2 → NP_732350.1  fruitless, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732350.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IN81
      Related
      FBpp0083067
      Conserved Domains (3) summary
      smart00225
      Location:31 → 115
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00597
      Location:559 → 634
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam00651
      Location:20 → 115
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG97 A0A0B4KG97
    E1JIP5 E1JIP5
    Q8IN81.1 Q8IN81

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