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    CG5860 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42095, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG5860provided by FlyBase
    Primary source
    FLYBASE:FBgn0038506
    Locus tag
    Dmel_CG5860
    See related
    AllianceGenome:FB:FBgn0038506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5860; FBgn0038506
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in cell death. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    90A6-90A6; 3-60 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17409619..17410840)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13235341..13236562)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assessment of genome-wide protein function classification for Drosophila melanogaster. Mi H, et al. Genome Res, 2003 Sep. PMID 12952880, Free PMC Article
    2. A Drosophila protein-interaction map centered on cell-cycle regulators. Stanyon CA, et al. Genome Biol, 2004. PMID 15575970, Free PMC Article
    3. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article
    4. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5860-PA
    NP_650622.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17409619..17410840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142365.2 → NP_650622.1  uncharacterized protein Dmel_CG5860 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650622.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEK4
      Related
      FBpp0082879
      Conserved Domains (2) summary
      pfam00026
      Location:63 → 369
      Asp; Eukaryotic aspartyl protease
      cl11403
      Location:61 → 368
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEK4 Q9VEK4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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