adgrv1 adhesion G protein-coupled receptor V1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adgrv1provided by ZNC
Official Full Name: adhesion G protein-coupled receptor V1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040624-6
See related: Ensembl:ENSDARG00000021137 AllianceGenome:ZFIN:ZDB-GENE-040624-6
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gpr98; mass1; vlgr1
Summary: Predicted to enable G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and adenylate cyclase inhibitor activity. Acts upstream of or within eye photoreceptor cell development. Predicted to be located in photoreceptor inner segment and stereocilium membrane. Predicted to be integral component of membrane. Is expressed in integument; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Usher syndrome type 2C and familial febrile seizures 4. Orthologous to human ADGRV1 (adhesion G protein-coupled receptor V1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 91

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (48683336..48940174)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (48031836..48288663)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In situ hybridization studies of zebrafish embryos demonstrate vlgr1 expression in the developing central nervous system, particularly in the hypothalamus, epiphysis and in the rhombic lips
Title: Analysis of the very large G-protein coupled receptor gene (Vlgr1/Mass1/USH2C) in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fj05f08.x1 (e-PCR)
- UniSTS:198402

GDB:1317392 (e-PCR)
- UniSTS:30988

D9S290 (e-PCR), detects polymorphism
- UniSTS:47999

G46660 (e-PCR)
- UniSTS:107460

fc27b06.x1 (e-PCR)
- UniSTS:187872

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G-protein alpha-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell communication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within eye photoreceptor cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in system development	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in stereocilium	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adhesion G-protein coupled receptor V1; G-protein coupled receptor 98

Names: monogenic audiogenic seizure susceptibility protein 1 homolog; monogenic, audiogenic seizure susceptibility 1 homolog; very large G-protein coupled receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001845.2 → NP_001001845.2 adhesion G-protein coupled receptor V1 precursor

Status: VALIDATED

Source sequence(s)

AL929202, CR407555, CU928045

UniProtKB/Swiss-Prot

Q6JAN0

UniProtKB/TrEMBL

A0A8M1MZR4, F1QEZ1

Related

ENSDARP00000020853.7, ENSDART00000008043.9

Conserved Domains (3) summary

pfam13385
Location:1343 → 1484

Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily

cl02522
Location:4247 → 4335

Calx-beta; Calx-beta domain

cl21561
Location:5861 → 5916

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

48683336..48940174

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009301753.3 → XP_009300028.1 G-protein coupled receptor 98 isoform X1

UniProtKB/Swiss-Prot

Q6JAN0

UniProtKB/TrEMBL

A0A8M3ASR0

Conserved Domains (3) summary

pfam13385
Location:1343 → 1484

Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily

cl02522
Location:1712 → 1794

Calx-beta; Calx-beta domain

cl21561
Location:5871 → 5926

7tm_4; Olfactory receptor
XM_005165511.4 → XP_005165568.1 G-protein coupled receptor 98 isoform X2

UniProtKB/Swiss-Prot

Q6JAN0

UniProtKB/TrEMBL

A0A8M2BD08

Conserved Domains (3) summary

pfam13385
Location:1343 → 1484

Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily

cl02522
Location:1712 → 1794

Calx-beta; Calx-beta domain

cl21561
Location:5864 → 5919

7tm_4; Olfactory receptor