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    Art4 Arginine methyltransferase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41219, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Art4provided by FlyBase
    Official Full Name
    Arginine methyltransferase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0037770
    Locus tag
    Dmel_CG5358
    See related
    AllianceGenome:FB:FBgn0037770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CARM1; CG5358; dArt 4; Dart4; DART4; Dmel\CG5358; PRMT4
    Summary
    Enables histone methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; and protein-arginine omega-N monomethyltransferase activity. Involved in peptidyl-arginine methylation; positive regulation of ecdysone receptor-mediated signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Part of histone methyltransferase complex. Is expressed in several structures, including embryonic/larval digestive system; embryonic/larval nervous system; extended germ band embryo; imaginal disc; and ovary. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    85F4-85F4; 3-49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9982816..9986060, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5808538..5811782, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tipE homolog 1 Neighboring gene long non-coding RNA:CR45029 Neighboring gene uncharacterized protein Neighboring gene Glucose transporter 4 enhancer factor Neighboring gene mir-9371 stem loop Neighboring gene Gustatory receptor 85a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor. Kimura S, et al. Biochem Biophys Res Commun, 2008 Jul 11. PMID 18468516
    2. Tissue-dependent subcellular localization of Drosophila arginine methyl-transferase 4 (DART4), a coactivator whose overexpression affects neither viability nor differentiation. Urwyler O, et al. Differentiation, 2007 Oct. PMID 17459088
    3. The lncRNA hsrω regulates arginine dimethylation of human FUS to cause its proteasomal degradation in Drosophila. Lo Piccolo L, et al. J Cell Sci, 2019 Oct 23. PMID 31519807, Free PMC Article
    4. A novel BLAST-Based Relative Distance (BBRD) method can effectively group members of protein arginine methyltransferases and suggest their evolutionary relationship. Wang YC, et al. Mol Phylogenet Evol, 2015 Mar. PMID 25576770
    5. An arginine-histone methyltransferase, CARMER, coordinates ecdysone-mediated apoptosis in Drosophila cells. Cakouros D, et al. J Biol Chem, 2004 Apr 30. PMID 14976192

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone H3R17 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H3R2 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3R2 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone arginine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-arginine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-arginine omega-N asymmetric methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-arginine omega-N monomethyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ecdysone receptor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arginine methyltransferase 4
    Names
    Art4-PA
    Art4-PB
    CARMER
    CG5358-PA
    CG5358-PB
    arginie methyl transferase 4
    arginine methyl-transferase 4
    coactivator Arg methyltransferase for Ecr/Usp
    NP_001262445.1
    NP_649963.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9982816..9986060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275516.1 → NP_001262445.1  arginine methyltransferase 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262445.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86NL6, Q9VH48
      UniProtKB/TrEMBL
      F0JAI1
      Conserved Domains (3) summary
      cd02440
      Location:183 → 281
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam05185
      Location:53 → 430
      PRMT5; PRMT5 arginine-N-methyltransferase
      cl17171
      Location:24 → 134
      PH-like; Pleckstrin homology-like domain

    2. NM_141706.3 → NP_649963.1  arginine methyltransferase 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649963.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86NL6, Q9VH48
      UniProtKB/TrEMBL
      F0JAI1
      Related
      FBpp0081628
      Conserved Domains (3) summary
      cd02440
      Location:183 → 281
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam05185
      Location:53 → 430
      PRMT5; PRMT5 arginine-N-methyltransferase
      cl17171
      Location:24 → 134
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F0JAI1 F0JAI1
    Q9VH48.1 Q9VH48

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