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    p23 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41173, updated on 4-Apr-2024

    Summary

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    Official Symbol
    p23provided by FlyBase
    Primary source
    FLYBASE:FBgn0037728
    Locus tag
    Dmel_CG16817
    See related
    AllianceGenome:FB:FBgn0037728
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg16817; CG16817; Dmel\CG16817; YC17
    Summary
    Predicted to enable Hsp90 protein binding activity; chaperone binding activity; and prostaglandin-E synthase activity. Involved in positive regulation of small RNA loading onto RISC. Located in endoplasmic reticulum and nuclear membrane. Is expressed in adult head. Orthologous to several human genes including PTGES3 (prostaglandin E synthase 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See p23 in Genome Data Viewer
    Location:
    85E3-85E3; 3-49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9677927..9679658)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5503649..5505380)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Dynein heavy chain 1 Neighboring gene pseudo Neighboring gene Neprilysin-like 12 Neighboring gene nmdyn-D7 Neighboring gene uncharacterized protein Neighboring gene eclair

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conformational Activation of Argonaute by Distinct yet Coordinated Actions of the Hsp70 and Hsp90 Chaperone Systems. Tsuboyama K, et al. Mol Cell, 2018 May 17. PMID 29775584
    2. p23 and HSP20/alpha-crystallin proteins define a conserved sequence domain present in other eukaryotic protein families. Garcia-Ranea JA, et al. FEBS Lett, 2002 Oct 9. PMID 12372593
    3. Defining fundamental steps in the assembly of the Drosophila RNAi enzyme complex. Iwasaki S, et al. Nature, 2015 May 28. PMID 25822791
    4. Identifying calpain substrates in intact S2 cells of Drosophila. Bozoky Z, et al. Arch Biochem Biophys, 2009 Jan 15. PMID 19038228
    5. A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster. Scarpati M, et al. PLoS One, 2019. PMID 30753230, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prostaglandin-E synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RISC complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chaperone-mediated protein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    p23
    Names
    CG16817-PA
    CG16817-PB
    homolog to co-chaperone p23
    p23-PA
    p23-PB
    NP_001247010.1
    NP_649925.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9677927..9679658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141668.3 → NP_649925.1  p23, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649925.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VH95
      UniProtKB/TrEMBL
      A0A0B4K6D2, E8NH46
      Related
      FBpp0081560
      Conserved Domains (1) summary
      cd06465
      Location:10 → 117
      p23_hB-ind1_like; p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) ...

    2. NM_001260081.2 → NP_001247010.1  p23, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247010.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VH95
      UniProtKB/TrEMBL
      A0A0B4K6D2, E8NH46
      Conserved Domains (1) summary
      cd06465
      Location:10 → 117
      p23_hB-ind1_like; p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6D2 A0A0B4K6D2
    Q9VH95.1 Q9VH95

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