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    lclat1 lysocardiolipin acyltransferase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406554, updated on 11-Apr-2024

    Summary

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    Official Symbol
    lclat1provided by ZNC
    Official Full Name
    lysocardiolipin acyltransferase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081211-2
    See related
    Ensembl:ENSDARG00000103320 AllianceGenome:ZFIN:ZDB-GENE-081211-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lycat; lycat1; 1-AGPAT 8; zgc:77380; wu:fj17g04
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Acts upstream of or within endothelial cell development and hemangioblast cell differentiation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in hematopoietic stem cell. Orthologous to human LCLAT1 (lysocardiolipin acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (51956397..51963460)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (51747141..51754204)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene type I inositol 1,4,5-trisphosphate 5-phosphatase Neighboring gene zmp:0000000755 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene serum response factor b Neighboring gene kinesin light chain 1b Neighboring gene protein tyrosine kinase 7b Neighboring gene solute carrier family 30 member 10 Neighboring gene kelch domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation. Wang C, et al. Blood, 2007 Nov 15. PMID 17675553, Free PMC Article
    2. A zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment. Schorpp M, et al. Mech Dev, 2002 Oct. PMID 12351184
    3. Endocardium is necessary for cardiomyocyte movement during heart tube assembly. Holtzman NG, et al. Development, 2007 Jun. PMID 17537802
    4. Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafish. Lieschke GJ, et al. Blood, 2001 Nov 15. PMID 11698295
    5. Myelopoiesis in the zebrafish, Danio rerio. Bennett CM, et al. Blood, 2001 Aug 1. PMID 11468162

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that lycat is the earliest known player in the generation of both endothelial and hematopoietic lineages.
      Title: An acyltransferase controls the generation of hematopoietic and endothelial lineages in zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-methylhexanoyl-CoA C-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables keto acid formate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic hemopoiesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endothelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hemangioblast cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysocardiolipin acyltransferase 1
    Names
    1-AGP acyltransferase 8
    1-acylglycerol-3-phosphate O-acyltransferase 8
    acyl-CoA:lysocardiolipin acyltransferase 1
    NP_998435.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213270.2 → NP_998435.1  lysocardiolipin acyltransferase 1

      See identical proteins and their annotated locations for NP_998435.1

      Status: VALIDATED

      Source sequence(s)
      FO203516
      UniProtKB/Swiss-Prot
      Q6NYV8
      Related
      ENSDARP00000138738.1, ENSDART00000161098.2
      Conserved Domains (2) summary
      cd07990
      Location:55 → 248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:233 → 283
      Acyltransf_C; Acyltransferase C-terminus

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      51956397..51963460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NYV8.1 GenPept UniProtKB/Swiss-Prot:Q6NYV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.