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    amy2a amylase alpha 2A [ Danio rerio (zebrafish) ]

    Gene ID: 406539, updated on 27-Mar-2024

    Summary

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    Official Symbol
    amy2aprovided by ZNC
    Official Full Name
    amylase alpha 2Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2393
    See related
    Ensembl:ENSDARG00000013856 AllianceGenome:ZFIN:ZDB-GENE-040426-2393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    amy3; zgc:66270; zgc:77877; wu:fb64c06
    Summary
    Predicted to enable alpha-amylase activity; alpha-amylase activity (releasing maltohexaose); and metal ion binding activity. Predicted to act upstream of or within carbohydrate metabolic process. Is expressed in pancreas. Orthologous to several human genes including AMY2A (amylase alpha 2A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (15612763..15626972)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (15944173..15958382)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene collagen, type XI, alpha 1b Neighboring gene uncharacterized LOC100001444 Neighboring gene netrin-G1 Neighboring gene uncharacterized LOC101885853 Neighboring gene vav 3 guanine nucleotide exchange factor b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish model of KRAS-initiated pancreatic endocrine tumor. Oh S, et al. Anim Cells Syst (Seoul), 2019 Jun. PMID 31231585, Free PMC Article
    2. Programming effects of high-carbohydrate feeding of larvae on adult glucose metabolism in zebrafish, Danio rerio. Fang L, et al. Br J Nutr, 2014 Mar 14. PMID 24112146
    3. Defining the transcriptomic landscape of the developing enteric nervous system and its cellular environment. Roy-Carson S, et al. BMC Genomics, 2017 Apr 12. PMID 28403821, Free PMC Article
    4. White adipose tissue development in zebrafish is regulated by both developmental time and fish size. Imrie D, et al. Dev Dyn, 2010 Nov. PMID 20925116, Free PMC Article
    5. Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio. Venezia O, et al. Toxicol Appl Pharmacol, 2021 Sep 1. PMID 34302850, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alpha-amylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-amylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pancreatic alpha-amylase
    Names
    amylase alpha 2A (pancreatic)
    NP_998176.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213011.2 → NP_998176.2  pancreatic alpha-amylase precursor

      See identical proteins and their annotated locations for NP_998176.2

      Status: VALIDATED

      Source sequence(s)
      BC062867, CF103228
      UniProtKB/TrEMBL
      A0A8M1PG48, Q6P5J0
      Related
      ENSDARP00000021453.5, ENSDART00000003035.6
      Conserved Domains (2) summary
      cd11317
      Location:25 → 417
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:424 → 511
      Aamy_C; Aamy_C domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      15612763..15626972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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