sarm1 sterile alpha and TIR motif containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sarm1provided by ZNC
Official Full Name: sterile alpha and TIR motif containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040219-1
See related: Ensembl:ENSDARG00000010610 AllianceGenome:ZFIN:ZDB-GENE-040219-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables NAD+ nucleosidase activity. Involved in NAD catabolic process. Predicted to be located in axon; mitochondrion; and synapse. Predicted to be active in dendrite. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 15

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (28189552..28199762, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (28256676..28266886, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables NADP+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing N-glycosyl compounds	IEA Inferred from Electronic Annotation more info
enables signaling adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of MyD88-independent toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to axon injury	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: NAD(+) hydrolase SARM1

Names: NADP(+) hydrolase SARM1; NADase SARM1; sterile alpha and TIR motif-containing protein 1

NP_001124068.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130596.1 → NP_001124068.1 NAD(+) hydrolase SARM1

See identical proteins and their annotated locations for NP_001124068.1

Status: PROVISIONAL

Source sequence(s)

BC163770

UniProtKB/Swiss-Prot

B3DK97, F1QWA8, Q6TQG1

Related

ENSDARP00000014434.9, ENSDART00000004200.11

Conserved Domains (4) summary

cd09501
Location:405 → 473

SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1

cd09502
Location:474 → 543

SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2

smart00454
Location:405 → 472

SAM; Sterile alpha motif

smart00255
Location:554 → 691

TIR; Toll - interleukin 1 - resistance