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    CG7365 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40200, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG7365provided by FlyBase
    Primary source
    FLYBASE:FBgn0036939
    Locus tag
    Dmel_CG7365
    See related
    AllianceGenome:FB:FBgn0036939
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7365
    Summary
    Predicted to enable calcium-independent phospholipase A2 activity and lysophospholipase activity. Predicted to be involved in phospholipid metabolic process. Orthologous to human PLB1 (phospholipase B1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    76F2-76F2; 3-46 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20124298..20127381, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20117398..20120481, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 76b Neighboring gene uncharacterized protein Neighboring gene gigas Neighboring gene obstructor-J Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis. Pandey V, et al. Front Cell Neurosci, 2013. PMID 24058333, Free PMC Article
    2. Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat. Napoletano F, et al. EMBO J, 2011 Mar 2. PMID 21278706, Free PMC Article
    3. Identification of Drosophila gene products required for phagocytosis of Candida albicans. Stroschein-Stevenson SL, et al. PLoS Biol, 2006 Jan. PMID 16336044, Free PMC Article
    4. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
    5. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. Palu RA, et al. PLoS Genet, 2016 Apr. PMID 27058248, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-independent phospholipase A2 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7365-PA
    CG7365-PB
    NP_001262088.1
    NP_649178.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20124298..20127381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140921.3 → NP_649178.1  uncharacterized protein Dmel_CG7365, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649178.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VW80
      Related
      FBpp0074636
      Conserved Domains (1) summary
      cd01824
      Location:95 → 385
      Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...

    2. NM_001275159.1 → NP_001262088.1  uncharacterized protein Dmel_CG7365, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262088.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VW80
      Conserved Domains (1) summary
      cd01824
      Location:95 → 385
      Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VW80 Q9VW80

    Gene LinkOut

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