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    CG7484 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39969, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG7484provided by FlyBase
    Primary source
    FLYBASE:FBgn0036745
    Locus tag
    Dmel_CG7484
    See related
    AllianceGenome:FB:FBgn0036745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD16138; Dmel\CG7484; Prise 8; Sep15
    Summary
    Enables disulfide oxidoreductase activity. Predicted to be involved in cell redox homeostasis. Located in endoplasmic reticulum and nucleus. Is expressed in adult head. Orthologous to human SELENOF (selenoprotein F). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    74E4-74E4; 3-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17654617..17655645)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17647717..17648745)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nedd4 family interacting protein Neighboring gene Keren Neighboring gene CREB-regulated transcription coactivator Neighboring gene small non-coding RNA 641 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. Ferguson AD, et al. J Biol Chem, 2006 Feb 10. PMID 16319061
    2. A novel cysteine-rich domain of Sep15 mediates the interaction with UDP-glucose:glycoprotein glucosyltransferase. Labunskyy VM, et al. J Biol Chem, 2005 Nov 11. PMID 16129668
    3. Selenoproteins: molecular pathways and physiological roles. Labunskyy VM, et al. Physiol Rev, 2014 Jul. PMID 24987004, Free PMC Article
    4. The EGFR ligands Spitz and Keren act cooperatively in the Drosophila eye. Brown KE, et al. Dev Biol, 2007 Jul 1. PMID 17512517
    5. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sep15 and SelM have roles as thiol-disulfide oxidoreductases
      Title: NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione disulfide oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7484-PB
    NP_649000.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17654617..17655645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140743.2 → NP_649000.1  uncharacterized protein Dmel_CG7484 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649000.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0APL1, A0APL2, A0APL6, C0MK69, Q9VVJ7
      Related
      FBpp0074949
      Conserved Domains (1) summary
      pfam08806
      Location:74 → 148
      Sep15_SelM; Sep15/SelM redox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVJ7 Q9VVJ7

    Gene LinkOut

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