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    Ccdc56 Coiled-coil domain containing 56 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39320, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ccdc56provided by FlyBase
    Official Full Name
    Coiled-coil domain containing 56provided by FlyBase
    Primary source
    FLYBASE:FBgn0261353
    Locus tag
    Dmel_CG42630
    See related
    AllianceGenome:FB:FBgn0261353
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ccdc56; CCDC56; CG42630; CG7319; Coa3; Dmel\CG42630
    Old locus tag
    Dmel_CG7319
    Summary
    Involved in respiratory chain complex IV assembly. Located in mitochondrion. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COA3 (cytochrome c oxidase assembly factor 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    68D2-68D2; 3-36 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11708979..11710570)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11702079..11703670)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, intermediate chain 2 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial Transcription Factor B1 Neighboring gene crimpled Neighboring gene uncharacterized protein Neighboring gene bmcp

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila mitochondrial transcription factor B1 modulates mitochondrial translation but not transcription or DNA copy number in Schneider cells. Matsushima Y, et al. J Biol Chem, 2005 Apr 29. PMID 15749697
    2. Mitochondrial Cytochrome c Oxidase Defects Alter Cellular Homeostasis of Transition Metals. Brischigliaro M, et al. Front Cell Dev Biol, 2022. PMID 35663391, Free PMC Article
    3. Coiled coil domain-containing protein 56 (CCDC56) is a novel mitochondrial protein essential for cytochrome c oxidase function. Peralta S, et al. J Biol Chem, 2012 Jul 13. PMID 22610097, Free PMC Article
    4. Mitochondrial Neurodegeneration: Lessons from Drosophila melanogaster Models. Brischigliaro M, et al. Biomolecules, 2023 Feb 16. PMID 36830747, Free PMC Article
    5. Exhaustive identification of conserved upstream open reading frames with potential translational regulatory functions from animal genomes. Takahashi H, et al. Sci Rep, 2020 Oct 1. PMID 33004976, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate an important role for CCDC56 in the oxidative phosphorylation system and in particular in COX function required for proper development in D. melanogaster.
      Title: Coiled coil domain-containing protein 56 (CCDC56) is a novel mitochondrial protein essential for cytochrome c oxidase function.
    2. mitochondrial transcription factor B1 modulates mitochondrial translation but not transcription or DNA copy number in Schneider cells
      Title: Drosophila mitochondrial transcription factor B1 modulates mitochondrial translation but not transcription or DNA copy number in Schneider cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in respiratory chain complex IV assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Coiled-coil domain containing 56
    Names
    CG42630-PA
    CPuORF of FBgn0261381
    Ccdc56-PA
    mitochondrial transcription factor B1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11708979..11710570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206340.4 → NP_996062.3  Coiled-coil domain containing 56 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996062.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      N0BIP9, P0DKM0
      Conserved Domains (1) summary
      pfam09813
      Location:1 → 86
      Coiled-coil_56; Coiled-coil domain-containing protein 56
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DKM0.1 P0DKM0

    Gene LinkOut

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