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    Pstk Phosphoseryl tRNA kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772080, updated on 29-Dec-2023

    Summary

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    Official Symbol
    Pstkprovided by FlyBase
    Official Full Name
    Phosphoseryl tRNA kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031041
    Locus tag
    Dmel_CG12788
    See related
    AllianceGenome:FB:FBgn0031041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12788; CG33066; Dmel\CG12788; Dromel_CG12788_CG17767_FBtr0074_tim9b_mORF; phosphoseryl tRNA kinase; PSTK
    Summary
    Predicted to enable L-seryl-tRNA(Sec) kinase activity and tRNA binding activity. Is expressed in organism. Orthologous to human PSTK (phosphoseryl-tRNA kinase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Pstk in Genome Data Viewer
    Location:
    18D3-18D7; 1-63 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19616663..19618537, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19510696..19512570, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tyler Neighboring gene shawn Neighboring gene uncharacterized protein Neighboring gene Translocase of inner membrane 9b Neighboring gene uncharacterized protein Neighboring gene N(alpha)-acetyltransferase 20 A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase. Carlson BA, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15317934, Free PMC Article
    2. Relaxation of selective constraints causes independent selenoprotein extinction in insect genomes. Chapple CE, et al. PLoS One, 2008 Aug 13. PMID 18698431, Free PMC Article
    3. Control of Cell Growth and Proliferation by the Tribbles Pseudokinase: Lessons from Drosophila. Dobens LL, et al. Cancers (Basel), 2021 Feb 20. PMID 33672471, Free PMC Article
    4. Comparative genomic analysis of novel conserved peptide upstream open reading frames in Drosophila melanogaster and other dipteran species. Hayden CA, et al. BMC Genomics, 2008 Feb 1. PMID 18237443, Free PMC Article
    5. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-seryl-tRNA(Sec) kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    phosphoseryl tRNA kinase
    Names
    CG12788-PA
    CG12788-PC
    CG12788-PE
    Pstk-PA
    Pstk-PC
    Pstk-PE
    NP_001259711.1
    NP_001259712.1
    NP_608329.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19616663..19618537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272783.1 → NP_001259712.1  phosphoseryl tRNA kinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWF7
      Conserved Domains (2) summary
      pfam13671
      Location:6 → 165
      AAA_33; AAA domain
      cl17190
      Location:4 → 267
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    2. NM_134485.4 → NP_608329.1  phosphoseryl tRNA kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608329.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWF7
      Conserved Domains (2) summary
      pfam13671
      Location:6 → 165
      AAA_33; AAA domain
      cl17190
      Location:4 → 267
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    3. NM_001272782.2 → NP_001259711.1  phosphoseryl tRNA kinase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259711.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWF7
      Conserved Domains (2) summary
      pfam13671
      Location:6 → 165
      AAA_33; AAA domain
      cl17190
      Location:4 → 267
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWF7 Q9VWF7

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