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    Alp8 Alkaline phosphatase 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37540, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Alp8provided by FlyBase
    Official Full Name
    Alkaline phosphatase 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0034712
    Locus tag
    Dmel_CG3264
    See related
    AllianceGenome:FB:FBgn0034712
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3264; Dmel\CG3264
    Summary
    Predicted to enable alkaline phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be located in cell surface. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and inflammatory bowel disease. Orthologous to several human genes including ALPL (alkaline phosphatase, biomineralization associated); ALPG (alkaline phosphatase, germ cell); and ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    58D1-58D1; 2-99 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22208464..22210765, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18095969..18098270, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Alkaline phosphatase 7 Neighboring gene Alkaline phosphatase 2 Neighboring gene uncharacterized protein Neighboring gene ariadne 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease. Garrido-Maraver J, et al. Biol Open, 2020 Jan 14. PMID 31822473, Free PMC Article
    2. A deletion-generator compound element allows deletion saturation analysis for genomewide phenotypic annotation. Huet F, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12096187, Free PMC Article
    3. Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc. Yepiskoposyan H, et al. Nucleic Acids Res, 2006. PMID 16973896, Free PMC Article
    4. The progesterone antagonist mifepristone/RU486 blocks the negative effect on life span caused by mating in female Drosophila. Landis GN, et al. Aging (Albany NY), 2015 Jan. PMID 25614682, Free PMC Article
    5. Genome-wide identification and comparative analysis of Cry toxin receptor families in 7 insect species with a focus on Spodoptera litura. Li Q, et al. Insect Sci, 2022 Jun. PMID 34405540

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkaline phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    alkaline phosphatase 8
    Names
    Alp8-PA
    Alp8-PB
    CG3264-PA
    CG3264-PB
    NP_001286709.1
    NP_611655.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22208464..22210765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299780.1 → NP_001286709.1  alkaline phosphatase 8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286709.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W273
      Conserved Domains (1) summary
      cl23718
      Location:88 → 525
      ALP_like; alkaline phosphatases and sulfatases

    2. NM_137811.3 → NP_611655.1  alkaline phosphatase 8, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611655.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W273
      Related
      FBpp0071694
      Conserved Domains (1) summary
      cl23718
      Location:88 → 525
      ALP_like; alkaline phosphatases and sulfatases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W273 Q9W273

    Gene LinkOut

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