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    Maff MAF bZIP transcription factor F [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366960, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Maffprovided by RGD
    Official Full Name
    MAF bZIP transcription factor Fprovided by RGD
    Primary source
    RGD:1309531
    See related
    Ensembl:ENSRNOG00000012886 AllianceGenome:RGD:1309531
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of epidermal cell differentiation. Predicted to act upstream of or within in utero embryonic development and skeletal muscle cell differentiation. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in nucleus. Orthologous to human MAFF (MAF bZIP transcription factor F). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 51.3), Lung (RPKM 41.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Maff in Genome Data Viewer
    Location:
    7q34
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112792787..112804139)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110912367..110923711)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120580743..120592095)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2 Neighboring gene phospholipase A2 group VI Neighboring gene transmembrane protein 184B Neighboring gene casein kinase 1, epsilon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Motohashi H, et al. Proc Natl Acad Sci U S A, 2004 Apr 27. PMID 15087497, Free PMC Article
    2. Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation. Marini MG, et al. Blood Cells Mol Dis, 2002 Sep-Oct. PMID 12490281
    3. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD, et al. Trends Biochem Sci, 2014 Apr. PMID 24647116
    4. DNA-binding specificities of human transcription factors. Jolma A, et al. Cell, 2013 Jan 17. PMID 23332764
    5. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Rajan S, et al. Physiol Genomics, 2012 Feb 1. PMID 22147266

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of epidermal cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of epidermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor MafF
    Names
    v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
    v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F
    v-maf musculoaponeurotic fibrosarcoma oncogene homolog F

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130573.2 → NP_001124045.1  transcription factor MafF

      See identical proteins and their annotated locations for NP_001124045.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I5ZUD9, A6HSR5, D3ZC87
      Related
      ENSRNOP00000017181.4, ENSRNOT00000017181.5
      Conserved Domains (2) summary
      cd14717
      Location:47 → 115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
      cl28929
      Location:78 → 156
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112792787..112804139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242029.5 → XP_006242091.2  transcription factor MafF isoform X1

      Conserved Domains (1) summary
      cd14717
      Location:153 → 221
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version

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