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    CG30022 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36233, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG30022provided by FlyBase
    Primary source
    FLYBASE:FBgn0050022
    Locus tag
    Dmel_CG30022
    See related
    AllianceGenome:FB:FBgn0050022
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE56416; CG9026; Dmel\CG30022
    Summary
    Predicted to enable iron ion binding activity and sulfur dioxygenase activity. Predicted to be involved in glutathione metabolic process and hydrogen sulfide metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in ethylmalonic encephalopathy. Orthologous to human ETHE1 (ETHE1 persulfide dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    47F8-47F8; 2-64 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11387160..11388779, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7274665..7276284, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 47F Neighboring gene Superoxide dismutase 3 Neighboring gene sprite Neighboring gene transfer RNA:Threonine-TGT 2-1 Neighboring gene transfer RNA:Threonine-TGT 2-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of conserved transcriptome features between humans and Drosophila in the aging brain utilizing machine learning on combined data from the NIH Sequence Read Archive. Webb JL, et al. PLoS One, 2021. PMID 34379632, Free PMC Article
    2. Drosophila as a diet discovery tool for treating amino acid disorders. Mele S, et al. Trends Endocrinol Metab, 2023 Feb. PMID 36567227
    3. Genomewide analysis of Drosophila GAGA factor target genes reveals context-dependent DNA binding. van Steensel B, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12601174, Free PMC Article
    4. Spitz from the retina regulates genes transcribed in the second mitotic wave, peripodial epithelium, glia and plasmatocytes of the Drosophila eye imaginal disc. Firth LC, et al. Dev Biol, 2007 Jul 15. PMID 17553483, Free PMC Article
    5. Adaptation to Chronic Nutritional Stress Leads to Reduced Dependence on Microbiota in Drosophila melanogaster. Erkosar B, et al. mBio, 2017 Oct 24. PMID 29066546, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sulfur dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfur dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfur dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hydrogen sulfide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG30022-PB
    NP_725047.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11387160..11388779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165830.3 → NP_725047.2  uncharacterized protein Dmel_CG30022 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725047.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8L2, Q86PD3
      Conserved Domains (2) summary
      PLN02962
      Location:45 → 277
      PLN02962; hydroxyacylglutathione hydrolase
      cd07724
      Location:49 → 221
      POD-like_MBL-fold; ETHE1 (PDO type I), persulfide dioxygenase A (PDOA, PDO type II) and related proteins; MBL-fold metallo-hydrolase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86PD3 Q86PD3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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