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    CG10839 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34944, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG10839provided by FlyBase
    Primary source
    FLYBASE:FBgn0028858
    Locus tag
    Dmel_CG10839
    See related
    AllianceGenome:FB:FBgn0028858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS07486.2; Dmel\CG10839
    Summary
    Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be active in cytoplasm. Is expressed in spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 16. Orthologous to human DNAL1 (dynein axonemal light chain 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    35E1-35E1; 2-51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15979486..15981455)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15979486..15981455)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene beaten path Ib Neighboring gene long non-coding RNA:CR43803 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43412 Neighboring gene long non-coding RNA:CR43825 Neighboring gene beaten path Ic

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary origin of regulatory regions of retrogenes in Drosophila. Bai Y, et al. BMC Genomics, 2008 May 22. PMID 18498650, Free PMC Article
    2. Comparative transcriptomics between Drosophila mojavensis and D. arizonae reveals transgressive gene expression and underexpression of spermatogenesis-related genes in hybrid testes. Banho CA, et al. Sci Rep, 2021 May 10. PMID 33972659, Free PMC Article
    3. Comparative genomics reveals a constant rate of origination and convergent acquisition of functional retrogenes in Drosophila. Bai Y, et al. Genome Biol, 2007. PMID 17233920, Free PMC Article
    4. Parent genes of retrotransposition-generated gene duplicates in Drosophila melanogaster have distinct expression profiles. Langille MG, et al. Genomics, 2007 Sep. PMID 17628393
    5. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10839-PA
    CG10839-PB
    CG10839-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15979486..15981455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259110.2 → NP_001246039.1  uncharacterized protein Dmel_CG10839, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246039.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PV37, Q9V3Q0
      Conserved Domains (4) summary
      cd00116
      Location:37 → 129
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:50 → 71
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:48 → 90
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:51 → 105
      LRR_8; Leucine rich repeat

    2. NM_001299040.1 → NP_001285969.1  uncharacterized protein Dmel_CG10839, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285969.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PV37, Q9V3Q0
      Conserved Domains (4) summary
      cd00116
      Location:37 → 129
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:50 → 71
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:48 → 90
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:51 → 105
      LRR_8; Leucine rich repeat

    3. NM_135932.5 → NP_609776.1  uncharacterized protein Dmel_CG10839, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PV37, Q9V3Q0
      Related
      FBpp0080358
      Conserved Domains (4) summary
      cd00116
      Location:37 → 129
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:50 → 71
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:48 → 90
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:51 → 105
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2XYB0 Q2XYB0
    Q9V3Q0 Q9V3Q0

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