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    ova ovaries absent [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34362, updated on 4-Apr-2024

    Summary

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    Official Symbol
    ovaprovided by FlyBase
    Official Full Name
    ovaries absentprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032197
    Locus tag
    Dmel_CG5694
    See related
    AllianceGenome:FB:FBgn0032197
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5694; Dmel\CG5694; Ova; Su(var)2-1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    31B1-31B1; 2-40 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10227760..10231692, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10227760..10231692, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Bcs1 chaperone Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation elongation factor 1 delta Neighboring gene methuselah-like 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterochromatin formation in Drosophila requires genome-wide histone deacetylation in cleavage chromatin before mid-blastula transition in early embryogenesis. Walther M, et al. Chromosoma, 2020 Mar. PMID 31950239, Free PMC Article
    2. Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing. Yang F, et al. Elife, 2019 Jan 16. PMID 30648969, Free PMC Article
    3. Sex comb on midleg (Scm) is a functional link between PcG-repressive complexes in Drosophila. Kang H, et al. Genes Dev, 2015 Jun 1. PMID 26063573, Free PMC Article
    4. Epigenetic regulation of drosophila germline stem cell maintenance and differentiation. Vidaurre V, et al. Dev Biol, 2021 May. PMID 33610541, Free PMC Article
    5. Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila. Caizzi R, et al. PLoS Genet, 2016 Aug. PMID 27513559, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ova acts to link the histone h3 lysine 4 demethylase dLsd1 to HP1a for local histone modifications.
      Title: Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ovaries absent
    Names
    CG5694-PA
    CG5694-PB
    ova-PA
    ova-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10227760..10231692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135516.3 → NP_609360.2  ovaries absent, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609360.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VL20
      Related
      FBpp0079543
      Conserved Domains (1) summary
      pfam10491
      Location:15 → 105
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    2. NM_164894.2 → NP_723535.1  ovaries absent, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VL20
      Related
      FBpp0079544
      Conserved Domains (1) summary
      pfam10491
      Location:15 → 105
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MQQ6 Q8MQQ6
    Q9VL20 Q9VL20

    Gene LinkOut

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