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    LManV Lysosomal alpha-mannosidase V [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34205, updated on 4-Apr-2024

    Summary

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    Official Symbol
    LManVprovided by FlyBase
    Official Full Name
    Lysosomal alpha-mannosidase Vprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032068
    Locus tag
    Dmel_CG9466
    See related
    AllianceGenome:FB:FBgn0032068
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9466; Dmel\CG9466
    Summary
    Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be active in lysosome. Is expressed in adult head; embryonic hindgut; embryonic midgut chamber; embryonic/larval midgut; and spermatozoon. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    29F1-29F1; 2-34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8772946..8776263, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8772946..8776263, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Lysosomal alpha-mannosidase III Neighboring gene Lysosomal alpha-mannosidase IV Neighboring gene Lysosomal alpha-mannosidase VI Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Juricic P, et al. Nat Aging, 2022 Sep. PMID 37118497, Free PMC Article
    2. Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila. Tain LS, et al. Elife, 2021 Apr 21. PMID 33879316, Free PMC Article
    3. Chronic exposure to the star polycation (SPc) nanocarrier in the larval stage adversely impairs life history traits in Drosophila melanogaster. Yan S, et al. J Nanobiotechnology, 2022 Dec 8. PMID 36482441, Free PMC Article
    4. Characterisation of class I and II α-mannosidases from Drosophila melanogaster. Nemčovičová I, et al. Glycoconj J, 2013 Dec. PMID 23979800
    5. Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth. Kemppainen E, et al. PLoS One, 2016. PMID 26812173, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal alpha-mannosidase V
    Names
    CG9466-PA
    CG9466-PB
    LManV-PA
    LManV-PB
    NP_001285763.1
    NP_609252.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8772946..8776263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298834.1 → NP_001285763.1  lysosomal alpha-mannosidase V, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285763.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLI0
      Conserved Domains (3) summary
      cd10810
      Location:37 → 311
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
      pfam07748
      Location:481 → 977
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      pfam09261
      Location:358 → 433
      Alpha-mann_mid; Alpha mannosidase, middle domain

    2. NM_135408.4 → NP_609252.1  lysosomal alpha-mannosidase V, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609252.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLI0
      Related
      FBpp0079344
      Conserved Domains (3) summary
      cd10810
      Location:37 → 311
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
      pfam07748
      Location:481 → 977
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      pfam09261
      Location:358 → 433
      Alpha-mann_mid; Alpha mannosidase, middle domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLI0 Q9VLI0

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