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    CG31661 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33330, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG31661provided by FlyBase
    Primary source
    FLYBASE:FBgn0051661
    Locus tag
    Dmel_CG31661
    See related
    AllianceGenome:FB:FBgn0051661
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10872; Dmel\CG31661
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Involved in eggshell chorion assembly. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CG31661 in Genome Data Viewer
    Location:
    22A2-22A2; 2-3 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1497243..1498583)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1497243..1498583)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44064 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An MMP liberates the Ninjurin A ectodomain to signal a loss of cell adhesion. Zhang S, et al. Genes Dev, 2006 Jul 15. PMID 16815999, Free PMC Article
    2. Drosophila eggshell production: identification of new genes and coordination by Pxt. Tootle TL, et al. PLoS One, 2011. PMID 21637834, Free PMC Article
    3. Identification of transcriptional responsive genes to acetic acid, ethanol, and 2-phenylethanol exposure in Drosophila melanogaster. Seong KM, et al. Pestic Biochem Physiol, 2020 May. PMID 32359537
    4. Transcriptomic identification and characterization of genes commonly responding to sublethal concentrations of six different insecticides in the common fruit fly, Drosophila melanogaster. Gao Y, et al. Pestic Biochem Physiol, 2021 Jun. PMID 33993970
    5. Dynamics of Dark-Fly Genome Under Environmental Selections. Izutsu M, et al. G3 (Bethesda), 2015 Dec 4. PMID 26637434, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in egg chorion assembly IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in egg chorion assembly IGC
    Inferred from Genomic Context
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in egg chorion IGC
    Inferred from Genomic Context
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31661-PA
    aspartic-type endopeptidase
    lysosomal aspartic protease
    NP_722707.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1497243..1498583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164420.2 → NP_722707.1  uncharacterized protein Dmel_CG31661 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722707.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ14
      Related
      FBpp0077597
      Conserved Domains (2) summary
      pfam00026
      Location:88 → 392
      Asp; Eukaryotic aspartyl protease
      cl11403
      Location:78 → 391
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQ14 Q9VQ14

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