Mblac1 metallo-beta-lactamase domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mblac1provided by MGI
Official Full Name: metallo-beta-lactamase domain containing 1provided by MGI
Primary source: MGI:MGI:2679717
See related: Ensembl:ENSMUSG00000049285 AllianceGenome:MGI:2679717
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable hydrolase activity and metal ion binding activity. Orthologous to human MBLAC1 (metallo-beta-lactamase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.98 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (138192576..138193883)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (138194314..138195621)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Optical Imaging Reveals Liver Metabolic Perturbations in Mblac1 Knockout Mice.
Title: Optical Imaging Reveals Liver Metabolic Perturbations in Mblac1 Knockout Mice.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in histone mRNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metallo-beta-lactamase domain-containing protein 1

Names: endoribonuclease MBLAC1

NP_808546.1

EC 3.-.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177878.3 → NP_808546.1 metallo-beta-lactamase domain-containing protein 1

See identical proteins and their annotated locations for NP_808546.1

Status: VALIDATED

Source sequence(s)

AI314927, AK049381

Consensus CDS

CCDS19796.1

UniProtKB/Swiss-Prot

Q8BWY4, Q8CHU7

Related

ENSMUSP00000052869.5, ENSMUST00000057773.5

Conserved Domains (2) summary

COG0491
Location:81 → 244

GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]

cd07711
Location:24 → 240

MBLAC1-like_MBL-fold; uncharacterized human metallo-beta-lactamase domain-containing protein 1 and related proteins; MBL-fold metallo hydrolase domain