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    tho2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326153, updated on 8-Apr-2024

    Summary

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    Official Symbol
    tho2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031390
    Locus tag
    Dmel_CG31671
    See related
    AllianceGenome:FB:FBgn0031390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31671; CG4263; Dmel\CG31671; macadamia; Tho2; THO2; Thoc2
    Summary
    Predicted to enable mRNA binding activity. Involved in mRNA export from nucleus in response to heat stress and oogenesis. Located in nucleus. Part of THO complex. Is expressed in egg chamber. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    22D1-22D1; 2-5 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2137350..2145187, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2137350..2145187, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glycogen phosphorylase Neighboring gene uncharacterized protein Neighboring gene Tubulin-binding cofactor D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin. Zhang G, et al. Cell Rep, 2018 Sep 25. PMID 30257203, Free PMC Article
    2. ENY2 protein forms a part of the THO complex of Drosophila melanogaster. Gurskiy DY, et al. Dokl Biochem Biophys, 2010 Jul-Aug. PMID 20714859
    3. A systems view of mRNP biology. Hieronymus H, et al. Genes Dev, 2004 Dec 1. PMID 15574591
    4. A genetic toolkit for studying transposon control in the Drosophila melanogaster ovary. ElMaghraby MF, et al. Genetics, 2022 Jan 4. PMID 34718559, Free PMC Article
    5. Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Le Thomas A, et al. Genes Dev, 2013 Feb 15. PMID 23392610, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA export from nucleus in response to heat stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of THO complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of THO complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription export complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tho2
    Names
    CG31671-PA
    CG31671-PB
    CG31671-PC
    tho2-PA
    tho2-PB
    tho2-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2137350..2145187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164454.2 → NP_722763.1  tho2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722763.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ76
      Related
      FBpp0077525
      Conserved Domains (4) summary
      pfam11262
      Location:939 → 1240
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:629 → 703
      Thoc2; Transcription- and export-related complex subunit
      pfam12871
      Location:1569 → 1638
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
      pfam16134
      Location:133 → 627
      THOC2_N; THO complex subunit 2 N-terminus

    2. NM_001272976.1 → NP_001259905.1  tho2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259905.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE28
      Conserved Domains (4) summary
      pfam11262
      Location:939 → 1240
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:629 → 703
      Thoc2; Transcription- and export-related complex subunit
      pfam12871
      Location:1569 → 1638
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
      pfam16134
      Location:133 → 627
      THOC2_N; THO complex subunit 2 N-terminus

    3. NM_134802.4 → NP_608646.3  tho2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608646.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCS8
      Conserved Domains (4) summary
      pfam11262
      Location:939 → 1240
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:629 → 703
      Thoc2; Transcription- and export-related complex subunit
      pfam12871
      Location:1570 → 1639
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
      pfam16134
      Location:133 → 627
      THOC2_N; THO complex subunit 2 N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QCS8 E2QCS8
    M9PE28 M9PE28
    Q960L4 Q960L4
    Q9VQ76 Q9VQ76

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