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    Cep295 centrosomal protein 295 [ Mus musculus (house mouse) ]

    Gene ID: 319675, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cep295provided by MGI
    Official Full Name
    centrosomal protein 295provided by MGI
    Primary source
    MGI:MGI:2442521
    See related
    Ensembl:ENSMUSG00000046111 AllianceGenome:MGI:2442521
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1131; Kiaa1731; 5830418K08Rik; 5832426L23Rik
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centriole replication; positive regulation of protein acetylation; and regulation of centrosome duplication. Predicted to be located in cytoplasm; mitotic spindle microtubule; and plasma membrane. Predicted to be active in centriole; centrosome; and cytosol. Orthologous to human CEP295 (centrosomal protein 295). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 4.7), testis adult (RPKM 4.0) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A2; 9 4.79 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15228210..15269145, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15316914..15357849, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, D Neighboring gene small nucleolar RNA SNORA32 Neighboring gene predicted gene, 22579 Neighboring gene small Cajal body-specific RNA 9 Neighboring gene predicted gene, 24339 Neighboring gene STARR-seq mESC enhancer starr_23377 Neighboring gene STARR-seq mESC enhancer starr_23378 Neighboring gene predicted gene, 34973 Neighboring gene STARR-seq mESC enhancer starr_23379 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
    2. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of centriole elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 295 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176976.5 → NP_795950.3  centrosomal protein of 295 kDa

      Status: VALIDATED

      Source sequence(s)
      AC154296, AC155259
      Consensus CDS
      CCDS52727.1
      UniProtKB/TrEMBL
      E9QPW4
      Related
      ENSMUSP00000096578.5, ENSMUST00000098979.12
      Conserved Domains (1) summary
      PTZ00121
      Location:26 → 538
      PTZ00121; MAEBL; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      15228210..15269145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155053.1 → XP_036010946.1  centrosomal protein of 295 kDa isoform X16

      UniProtKB/Swiss-Prot
      Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    2. XM_017313423.3 → XP_017168912.1  centrosomal protein of 295 kDa isoform X15

      UniProtKB/Swiss-Prot
      Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    3. XM_036155050.1 → XP_036010943.1  centrosomal protein of 295 kDa isoform X11

      UniProtKB/TrEMBL
      E9QPW4
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    4. XM_006510411.3 → XP_006510474.1  centrosomal protein of 295 kDa isoform X6

      UniProtKB/Swiss-Prot
      Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    5. XM_030244413.2 → XP_030100273.1  centrosomal protein of 295 kDa isoform X10

      UniProtKB/TrEMBL
      E9QPW4
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    6. XM_006510409.3 → XP_006510472.1  centrosomal protein of 295 kDa isoform X3

      UniProtKB/Swiss-Prot
      Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    7. XM_017313422.3 → XP_017168911.1  centrosomal protein of 295 kDa isoform X8

      UniProtKB/TrEMBL
      E9QPW4
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    8. XM_017313419.3 → XP_017168908.1  centrosomal protein of 295 kDa isoform X1

      UniProtKB/Swiss-Prot
      Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    9. XM_011242548.4 → XP_011240850.1  centrosomal protein of 295 kDa isoform X5

      UniProtKB/Swiss-Prot
      Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
      Conserved Domains (1) summary
      PTZ00121
      Location:47 → 391
      PTZ00121; MAEBL; Provisional

    10. XM_036155052.1 → XP_036010945.1  centrosomal protein of 295 kDa isoform X13

      UniProtKB/Swiss-Prot
      Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9

    11. XM_030244414.2 → XP_030100274.1  centrosomal protein of 295 kDa isoform X13

      UniProtKB/Swiss-Prot
      Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9

    12. XM_030244415.2 → XP_030100275.1  centrosomal protein of 295 kDa isoform X13

      UniProtKB/Swiss-Prot
      Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9

    13. XM_011242550.4 → XP_011240852.1  centrosomal protein of 295 kDa isoform X14

      UniProtKB/Swiss-Prot
      Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9

    14. XM_006510414.2 → XP_006510477.1  centrosomal protein of 295 kDa isoform X17

      UniProtKB/TrEMBL
      E9QPW4
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    15. XM_036155051.1 → XP_036010944.1  centrosomal protein of 295 kDa isoform X12

      UniProtKB/TrEMBL
      E9QPW4
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    16. XM_017313421.2 → XP_017168910.1  centrosomal protein of 295 kDa isoform X7

      UniProtKB/Swiss-Prot
      Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    17. XM_017313420.2 → XP_017168909.1  centrosomal protein of 295 kDa isoform X4

      UniProtKB/Swiss-Prot
      Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
      UniProtKB/TrEMBL
      A0A1N9NPH8
      Related
      ENSMUSP00000123788.4, ENSMUST00000161132.10
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    18. XM_030244412.1 → XP_030100272.1  centrosomal protein of 295 kDa isoform X9

      UniProtKB/TrEMBL
      E9QPW4
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    19. XM_011242547.2 → XP_011240849.1  centrosomal protein of 295 kDa isoform X2

      UniProtKB/Swiss-Prot
      Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    20. XM_017313424.3 → XP_017168913.1  centrosomal protein of 295 kDa isoform X18

      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQ48.3 GenPept UniProtKB/Swiss-Prot:Q8BQ48

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