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    Rpl17 ribosomal protein L17 [ Mus musculus (house mouse) ]

    Gene ID: 319195, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Rpl17provided by MGI
    Official Full Name
    ribosomal protein L17provided by MGI
    Primary source
    MGI:MGI:2448270
    See related
    Ensembl:ENSMUSG00000062328 AllianceGenome:MGI:2448270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable large ribosomal subunit rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and positive regulation of G1/S transition of mitotic cell cycle. Located in synapse. Is expressed in brain; central nervous system; embryo; pancreas epithelium; and retina. Orthologous to several human genes including RPL17-C18orf32 (RPL17-C18orf32 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 250.7), bladder adult (RPKM 230.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 E3; 18 50.96 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (75132049..75136455)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (74998978..75003381)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9030625G05 gene Neighboring gene lipase, endothelial Neighboring gene STARR-positive B cell enhancer ABC_E11004 Neighboring gene STARR-positive B cell enhancer ABC_E7609 Neighboring gene STARR-positive B cell enhancer ABC_E7610 Neighboring gene small nucleolar RNA, C/D box 58B Neighboring gene predicted gene, 23301 Neighboring gene cDNA sequence BC031181 Neighboring gene predicted gene, 26202 Neighboring gene dymeclin Neighboring gene STARR-seq mESC enhancer starr_45027 Neighboring gene predicted gene, 52344

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reduced expression of the mouse ribosomal protein Rpl17 alters the diversity of mature ribosomes by enhancing production of shortened 5.8S rRNA. Wang M, et al. RNA, 2015 Jul. PMID 25995445, Free PMC Article
    2. Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation. Smolock EM, et al. Circulation, 2012 Nov 13. PMID 23065385, Free PMC Article
    3. Steroidogenic factor 1 differentially regulates fetal and adult leydig cell development in male mice. Karpova T, et al. Biol Reprod, 2015 Oct. PMID 26269506, Free PMC Article
    4. Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication. Salinas E, et al. J Virol, 2016 Feb 1. PMID 26581985, Free PMC Article
    5. The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression. Nakagawa T, et al. iScience, 2020 Apr 24. PMID 32299058, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reducing the amount of Rpl17 in mouse cells led to stalled 60S subunit maturation, causing degradation of most of the synthesized precursors
      Title: Reduced expression of the mouse ribosomal protein Rpl17 alters the diversity of mature ribosomes by enhancing production of shortened 5.8S rRNA.
    2. Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation.
      Title: Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103289, MGC118163

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables large ribosomal subunit rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in A band ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL22
    Names
    60S ribosomal protein L17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002239.4 → NP_001002239.2  large ribosomal subunit protein uL22 isoform a

      See identical proteins and their annotated locations for NP_001002239.2

      Status: VALIDATED

      Source sequence(s)
      AC125122
      Consensus CDS
      CCDS29344.1
      UniProtKB/Swiss-Prot
      Q6ZWZ7, Q9CPR4
      UniProtKB/TrEMBL
      Q505B1
      Related
      ENSMUSP00000078654.6, ENSMUST00000079716.6
      Conserved Domains (1) summary
      PTZ00178
      Location:1 → 165
      PTZ00178; 60S ribosomal protein L17; Provisional

    2. NM_001405964.1 → NP_001392893.1  large ribosomal subunit protein uL22 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC125122
      UniProtKB/Swiss-Prot
      Q6ZWZ7, Q9CPR4

    3. NM_001405965.1 → NP_001392894.1  large ribosomal subunit protein uL22 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC125122

    4. NM_001405966.1 → NP_001392895.1  large ribosomal subunit protein uL22 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC125122

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      75132049..75136455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525996.1 → XP_006526059.1  large ribosomal subunit protein uL22 isoform X2

      See identical proteins and their annotated locations for XP_006526059.1

      UniProtKB/Swiss-Prot
      Q6ZWZ7, Q9CPR4
      UniProtKB/TrEMBL
      Q505B1
      Related
      ENSMUSP00000157556.2, ENSMUST00000237431.2
      Conserved Domains (1) summary
      PTZ00178
      Location:1 → 165
      PTZ00178; 60S ribosomal protein L17; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPR4.4 GenPept UniProtKB/Swiss-Prot:Q9CPR4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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