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    Slc9a7 solute carrier family 9 member A7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317170, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Slc9a7provided by RGD
    Official Full Name
    solute carrier family 9 member A7provided by RGD
    Primary source
    RGD:1561385
    See related
    Ensembl:ENSRNOG00000004150 AllianceGenome:RGD:1561385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nhe7
    Summary
    Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of Golgi lumen acidification; and sodium ion import across plasma membrane. Predicted to be located in recycling endosome membrane and trans-Golgi network. Predicted to be integral component of membrane. Predicted to be active in plasma membrane and recycling endosome. Human ortholog(s) of this gene implicated in X-linked intellectual developmental disorder 108. Orthologous to human SLC9A7 (solute carrier family 9 member A7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 109.5), Spleen (RPKM 100.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    Xq11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (4767578..4948602)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (2214064..2395052)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (2434918..2615936)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 39, pseudogene 2 Neighboring gene egl-9 family hypoxia-inducible factor 1, pseudogene 1 Neighboring gene actin, beta, pseudogene 7 Neighboring gene carbohydrate sulfotransferase 7 Neighboring gene actin, beta, pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A recurrent missense variant in SLC9A7 causes nonsyndromic X-linked intellectual disability with alteration of Golgi acidification and aberrant glycosylation. Khayat W, et al. Hum Mol Genet, 2019 Feb 15. PMID 30335141, Free PMC Article
    2. Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network. Numata M, et al. J Biol Chem, 2001 May 18. PMID 11279194
    3. Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7. Lin PJ, et al. J Cell Sci, 2005 May 1. PMID 15840657
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Secretory carrier membrane proteins participate in the shuttling of NHE7 (Slc9a7) between recycling vesicles and the trans-Golgi network.
      Title: Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables potassium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Golgi lumen acidification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium/hydrogen exchanger 7
    Names
    solute carrier family 9 (sodium/hydrogen exchanger), member 7
    solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401002.1 → NP_001387931.1  sodium/hydrogen exchanger 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      D3ZCI2
      Related
      ENSRNOP00000005623.7, ENSRNOT00000005623.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      4767578..4948602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256637.4 → XP_006256699.1  sodium/hydrogen exchanger 7 isoform X2

      Conserved Domains (1) summary
      pfam00999
      Location:177 → 536
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    2. XM_063280010.1 → XP_063136080.1  sodium/hydrogen exchanger 7 isoform X1

      UniProtKB/TrEMBL
      A6JZU5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108242.1: Suppressed sequence

      Description
      NM_001108242.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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