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    Adamts20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315263, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Adamts20provided by RGD
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif, 20provided by RGD
    Primary source
    RGD:1307725
    See related
    Ensembl:ENSRNOG00000033397 AllianceGenome:RGD:1307725
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to act upstream of or within several processes, including negative regulation of apoptotic process; positive regulation of melanocyte differentiation; and proteolysis. Predicted to be located in extracellular space. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS20 (ADAM metallopeptidase with thrombospondin type 1 motif 20). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 62.5) and Brain (RPKM 14.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adamts20 in Genome Data Viewer
    Location:
    7q35
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (127275538..127407325, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (125396227..125528020, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (135465021..135630941, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093714 Neighboring gene uncharacterized LOC134479610 Neighboring gene uncharacterized LOC134479779 Neighboring gene uncharacterized LOC108351538 Neighboring gene uncharacterized LOC108351537 Neighboring gene pseudouridine synthase 7 like Neighboring gene interleukin-1 receptor-associated kinase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. AN EXPERIMENTAL INVESTIGATION OF PATTERN DEVELOPMENT IN LETHAL SPOTTING AND BELTED MOUSE EMBRYOS. MAYER TC, et al. Dev Biol, 1964 Apr. PMID 14138974
    2. Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain. Llamazares M, et al. J Biol Chem, 2003 Apr 11. PMID 12562771
    3. The secreted metalloprotease ADAMTS20 is required for melanoblast survival. Silver DL, et al. PLoS Genet, 2008 Feb 29. PMID 18454205, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of melanocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of melanocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of developmental pigmentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 20
    Names
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421315.1 → NP_001408244.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 precursor

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K836
      Related
      ENSRNOP00000074456.2, ENSRNOT00000088223.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      127275538..127407325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080333.2 → XP_038936261.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X1

      Conserved Domains (7) summary
      smart00209
      Location:558 → 610
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:257 → 463
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:720 → 838
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:41 → 186
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08685
      Location:1713 → 1880
      GON; GON domain
      pfam17771
      Location:478 → 545
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:1078 → 1132
      TSP1_ADAMTS; Thrombospondin type 1 domain

    2. XM_039080335.2 → XP_038936263.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X2

      Conserved Domains (5) summary
      smart00209
      Location:68 → 120
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:230 → 348
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08685
      Location:1223 → 1390
      GON; GON domain
      pfam17771
      Location:1 → 55
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:588 → 642
      TSP1_ADAMTS; Thrombospondin type 1 domain

    3. XM_039080336.1 → XP_038936264.1  A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X3

      Conserved Domains (3) summary
      pfam05986
      Location:140 → 258
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08685
      Location:1133 → 1300
      GON; GON domain
      pfam19030
      Location:498 → 552
      TSP1_ADAMTS; Thrombospondin type 1 domain

    RNA

    1. XR_005487344.2 RNA Sequence

    2. XR_005487345.2 RNA Sequence

    3. XR_005487346.2 RNA Sequence

    4. XR_005487347.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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