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    fs(1)Yb female sterile (1) Yb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31262, updated on 4-Apr-2024

    Summary

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    Official Symbol
    fs(1)Ybprovided by FlyBase
    Official Full Name
    female sterile (1) Ybprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000928
    Locus tag
    Dmel_CG2706
    See related
    AllianceGenome:FB:FBgn0000928
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2706; Dmel\CG2706; EG:95B7.8; fs(1)M104; Fs(1)Yb; fs(1)Y[b]; nov; yb; Yb; YB
    Summary
    Involved in germ-line stem cell division; germ-line stem cell population maintenance; and oogenesis. Located in Yb body. Is expressed in gonad. Orthologous to human TDRD12 (tudor domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    3B3-3B3; 1-1.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2720468..2724158)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2614501..2618191)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene female sterile (1) Young arrest Neighboring gene vilya

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila maternal-effect gene fs(1)Ya encodes a cell cycle-dependent nuclear envelope component required for embryonic mitosis. Lin HF, et al. Cell, 1991 Jan 11. PMID 1986869
    2. flam piRNA precursors channel from the nucleus to the cytoplasm in a temporally regulated manner along Drosophila oogenesis. Dennis C, et al. Mob DNA, 2019. PMID 31312260, Free PMC Article
    3. Mutational analyses of fs(1)Ya, an essential, developmentally regulated, nuclear envelope protein in Drosophila. Liu J, et al. Genetics, 1995 Dec. PMID 8601487, Free PMC Article
    4. Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly. Murota Y, et al. Cell Rep, 2014 Jul 10. PMID 24953657
    5. Nonessential Sequences, Genes, and the Polytene Chromosome Bands of DROSOPHILA MELANOGASTER. Young MW, et al. Genetics, 1978 Apr. PMID 17248815, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings shed light on distinct and collaborative requirements of Yb and Armi in transposon-targeting piRNA biogenesis.
      Title: Distinct and Collaborative Functions of Yb and Armitage in Transposon-Targeting piRNA Biogenesis.
    2. The Hel-C and eTud domains of Yb are crucial for Yb-Yb interactions and Yb binding with piRNA precursors.
      Title: Requirements for multivalent Yb body assembly in transposon silencing in Drosophila.
    3. We conclude that transcripts bound by Armi and Yb are identified as piRNA precursors, resulting in localization to cytoplasmic processing granules and their subsequent engagement by the resident piRNA biogenesis machinery.
      Title: Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries.
    4. Yb directly binds flam transcripts, but not neighboring protein-coding gene mRNAs.
      Title: Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly.
    5. Drosophila TUDOR domain-containing proteins interact with Vreteno and the Tdrd12 family, essential primary piRNA pathway factors
      Title: A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors.
    6. roles for the cytoplasmic Yb body components Armitage and Yb in somatic primary piRNA biogenesis
      Title: Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila.
    7. Yb protein is localized as discrete cytoplasmic spots exclusively in the somatic cells of the ovary and testis.
      Title: The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular condensate scaffold activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line stem cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ-line stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in primary piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Yb body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Yb body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    female sterile (1) Yb
    Names
    CG2706-PA
    female sterile(1)M104
    female sterile(1)Yb
    fs(1)Yb-PA
    no ovaries

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2720468..2724158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058146.4 → NP_477494.2  female sterile (1) Yb [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477494.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76911, Q9W4W2
      Related
      FBpp0070462
      Conserved Domains (1) summary
      pfam00567
      Location:859 → 948
      TUDOR; Tudor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MZ98 Q8MZ98
    Q9UB20 Q9UB20
    Q9W4W2 Q9W4W2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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