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    moody [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31168, updated on 4-Apr-2024

    Summary

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    Official Symbol
    moodyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025631
    Locus tag
    Dmel_CG4322
    See related
    AllianceGenome:FB:FBgn0025631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1631; CG4322; Dmel\CG4322; EG:22E5.11; EP1631; Moody
    Summary
    Predicted to enable G protein-coupled receptor activity. Involved in several processes, including behavioral response to cocaine; behavioral response to ethanol; and central nervous system development. Located in plasma membrane and pleated septate junction. Is expressed in several structures, including embryonic/larval nervous system; extended germ band embryo; glial cell; imaginal disc; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including MTNR1A (melatonin receptor 1A) and MTNR1B (melatonin receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    2C7-2C8; 1-0.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2044292..2050120, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1938325..1944153, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene alpha actinin Neighboring gene ultraspiracle Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44896 Neighboring gene Salt-inducible kinase 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic analysis of the mesenchymal-epithelial transition of blood-brain barrier forming glia in Drosophila. Schwabe T, et al. Biol Open, 2017 Feb 15. PMID 28108476, Free PMC Article
    2. Oatp58Dc contributes to blood-brain barrier function by excluding organic anions from the Drosophila brain. Seabrooke S, et al. Am J Physiol Cell Physiol, 2013 Sep. PMID 23804204
    3. Investigation of Evolutionary History and Origin of the Tre1 Family Suggests a Role in Regulating Hemocytes Cells Infiltration of the Blood-Brain Barrier. Kubick N, et al. Insects, 2021 Sep 29. PMID 34680651, Free PMC Article
    4. TU-tagging: cell type-specific RNA isolation from intact complex tissues. Miller MR, et al. Nat Methods, 2009 Jun. PMID 19430475, Free PMC Article
    5. Downregulation of oxidative stress-mediated glial innate immune response suppresses seizures in a fly epilepsy model. Nukala KM, et al. Cell Rep, 2023 Jan 31. PMID 36641750, Free PMC Article

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood-brain barrier formation and maturation.
      Title: The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood-brain barrier formation and maturation.
    2. RNAi-based screens uncover a potential new role for the orphan neuropeptide receptor Moody in Drosophila female germline stem cell maintenance.
      Title: RNAi-based screens uncover a potential new role for the orphan neuropeptide receptor Moody in Drosophila female germline stem cell maintenance.
    3. The results suggest a mechanism by which the Drosophila BBB is maintained by Moody/GPCR-dependent formation of ARSs, which is supported by myosin activation.
      Title: The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structures.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in axon ensheathment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of glial blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pleated septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    moody
    Names
    CG4322-PA
    CG4322-PB
    CG4322-PC
    CG4322-PD
    CG4322-PE
    CG4322-PF
    moody receptor
    moody-PA
    moody-PB
    moody-PC
    moody-PD
    moody-PE
    moody-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2044292..2050120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201607.2 → NP_001188536.1  moody, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188536.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS14
      Conserved Domains (2) summary
      pfam00001
      Location:53 → 363
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:44 → 167
      7tm_4; Olfactory receptor

    2. NM_001201605.2 → NP_001188534.1  moody, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188534.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77270, Q8MRD0, Q9W534
      UniProtKB/TrEMBL
      M9PDK4
      Conserved Domains (2) summary
      pfam00001
      Location:53 → 363
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:44 → 167
      7tm_4; Olfactory receptor

    3. NM_001272241.2 → NP_001259170.1  moody, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259170.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77270, Q8MRD0, Q9W534
      UniProtKB/TrEMBL
      M9PDK4
      Conserved Domains (2) summary
      pfam00001
      Location:53 → 363
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:44 → 167
      7tm_4; Olfactory receptor

    4. NM_001201606.2 → NP_001188535.1  moody, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS14
      Conserved Domains (2) summary
      pfam00001
      Location:53 → 363
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:44 → 167
      7tm_4; Olfactory receptor

    5. NM_130614.4 → NP_569970.2  moody, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569970.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77270, Q8MRD0, Q9W534
      UniProtKB/TrEMBL
      M9PDK4
      Related
      FBpp0070327
      Conserved Domains (2) summary
      pfam00001
      Location:53 → 363
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:44 → 167
      7tm_4; Olfactory receptor

    6. NM_001272242.2 → NP_001259171.1  moody, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259171.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77270, Q8MRD0, Q9W534
      UniProtKB/TrEMBL
      M9PDK4
      Conserved Domains (2) summary
      pfam00001
      Location:53 → 363
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:44 → 167
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MS14 M9MS14
    M9PDK4 M9PDK4
    Q9W534.2 Q9W534

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