Net1 neuroepithelial cell transforming 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Net1provided by RGD
Official Full Name: neuroepithelial cell transforming 1provided by RGD
Primary source: RGD:1305034
See related: Ensembl:ENSRNOG00000017765 AllianceGenome:RGD:1305034
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in several processes, including cellular response to hydrogen peroxide; positive regulation of GTPase activity; and positive regulation of Rho protein signal transduction. Predicted to act upstream of or within myoblast migration and positive regulation of substrate adhesion-dependent cell spreading. Predicted to be located in nucleus and plasma membrane. Orthologous to human NET1 (neuroepithelial cell transforming 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 413.1), Lung (RPKM 408.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (71251145..71280345)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (66341251..66370445)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (69991786..70020977)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myoblast migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuroepithelial cell-transforming gene 1 protein

Names: neuroepithelial cell transforming gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039023.1 → NP_001034112.1 neuroepithelial cell-transforming gene 1 protein

See identical proteins and their annotated locations for NP_001034112.1

Status: PROVISIONAL

Source sequence(s)

BC100154

UniProtKB/TrEMBL

A6JLQ2, Q498M6

Related

ENSRNOP00000023945.2, ENSRNOT00000023945.5

Conserved Domains (3) summary

smart00325
Location:124 → 300

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd13224
Location:314 → 448

PH_Net1; Neuroepithelial cell transforming 1 Pleckstrin homology (PH) domain

pfam00169
Location:333 → 447

PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

71251145..71280345

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254206.5 → XP_006254268.1 neuroepithelial cell-transforming gene 1 protein isoform X1

UniProtKB/TrEMBL

A0A8I6AVA8

Related

ENSRNOP00000092157.1

Conserved Domains (3) summary

smart00325
Location:178 → 354

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd13224
Location:368 → 502

PH_Net1; Neuroepithelial cell transforming 1 Pleckstrin homology (PH) domain

pfam00169
Location:387 → 501

PH; PH domain