Unc45b unc-45 myosin chaperone B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Unc45bprovided by RGD
Official Full Name: unc-45 myosin chaperone Bprovided by RGD
Primary source: RGD:1305666
See related: AllianceGenome:RGD:1305666
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cmya4
Summary: Predicted to enable Hsp90 protein binding activity. Predicted to be involved in chaperone-mediated protein folding. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in cataract 43 and myofibrillar myopathy. Orthologous to human UNC45B (unc-45 myosin chaperone B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 474.2) and Muscle (RPKM 451.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (68343011..68370683)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (67845464..67873143)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (70262340..70290445)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Unc45b (e-PCR), detects polymorphism
- UniSTS:259446

D10Chm175 (e-PCR)
- UniSTS:518063

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein folding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein unc-45 homolog B

Names: cardiomyopathy associated 4; unc-45 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.