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    Rgs4 regulator of G-protein signaling 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29480, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Rgs4provided by RGD
    Official Full Name
    regulator of G-protein signaling 4provided by RGD
    Primary source
    RGD:3567
    See related
    Ensembl:ENSRNOG00000002773 AllianceGenome:RGD:3567
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables G-protein alpha-subunit binding activity and GTPase activator activity. Involved in several processes, including regulation of ion transport; regulation of signal transduction; and response to alkaloid. Located in cytosol; nucleus; and plasma membrane. Part of protein-containing complex. Used to study epilepsy. Biomarker of bladder disease; hypertension; lesion of sciatic nerve; opioid abuse; and status epilepticus. Orthologous to human RGS4 (regulator of G protein signaling 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 760.9), Adrenal (RPKM 271.2) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rgs4 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (84469593..84475884, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (81936775..81943103, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (88054817..88061108, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 7 Neighboring gene NUF2 component of NDC80 kinetochore complex Neighboring gene regulator of G-protein signaling 5 Neighboring gene uncharacterized LOC134481531 Neighboring gene coiled-coil domain containing 190 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The roles of ubiquitin-proteasome system and regulator of G protein signaling 4 in behavioral sensitization induced by a single morphine exposure. Wang Y, et al. Brain Behav, 2023 Mar. PMID 36793204, Free PMC Article
    2. The antiepileptogenic effect of low-frequency stimulation on perforant path kindling involves changes in regulators of G-protein signaling in rat. Namvar S, et al. J Neurol Sci, 2017 Apr 15. PMID 28320185
    3. Development of a bimolecular luminescence complementation assay for RGS: G protein interactions in cells. Bodle CR, et al. Anal Biochem, 2017 Apr 1. PMID 28115169, Free PMC Article
    4. A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity. Taccola G, et al. Exp Neurol, 2016 Dec. PMID 27641322
    5. Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors. Blazer LL, et al. ACS Chem Neurosci, 2015 Jun 17. PMID 25844489

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The roles of ubiquitin-proteasome system and regulator of G protein signaling 4 in behavioral sensitization induced by a single morphine exposure.
      Title: The roles of ubiquitin-proteasome system and regulator of G protein signaling 4 in behavioral sensitization induced by a single morphine exposure.
    2. Synergistic regulation of Rgs4 mRNA by HuR and miR-26/RISC in neurons.
      Title: Synergistic regulation of Rgs4 mRNA by HuR and miR-26/RISC in neurons.
    3. LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression.
      Title: LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression.
    4. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling
      Title: Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling.
    5. After alphao dissociates from MOR, RGS4 remains bound to the C-terminal region of MOR
      Title: Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP-dependent manner.
    6. Data suggest that RGS4 proteins play an important pathophysiological role in the development and expression of l-DOPA-induced dyskinesia
      Title: RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease.
    7. partial agonism of the M2 muscarinic receptor is regulated by the RGS4-mediated inhibition of G-protein signalling
      Title: RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents.
    8. Tra2beta regulates the expression of RGS4 gene and is induced by morphine.
      Title: Splicing factor transformer-2β (Tra2β) regulates the expression of regulator of G protein signaling 4 (RGS4) gene and is induced by morphine.
    9. Rgs4 transcript is readily detected but does not respond to hypoxia. Furthermore, this regulation was found to be dependent on transcription, and occurs in a manner consistent with direct HIF transactivation of Rgs4 transcription
      Title: Hypoxic induction of the regulator of G-protein signalling 4 gene is mediated by the hypoxia-inducible factor pathway.
    10. data demonstrate that RGS4 in the dorsal striatum attenuates amphetamine-induced ERK signaling and decreases the behavioral efficacy of acute amphetamine likely by limiting mGluR5 function
      Title: RGS4 overexpression in the rat dorsal striatum modulates mGluR5- and amphetamine-mediated behavior and signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dorsal root ganglion development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell growth involved in cardiac muscle cell development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of dopamine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of glycine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin filament organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to amphetamine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to cocaine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulator of G-protein signaling 4
    Names
    RGP4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017214.2 → NP_058910.1  regulator of G-protein signaling 4

      See identical proteins and their annotated locations for NP_058910.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      P49799
      UniProtKB/TrEMBL
      A0A8I5Y8W6, A6IDM9
      Related
      ENSRNOP00000003774.2, ENSRNOT00000003774.3
      Conserved Domains (1) summary
      cd08714
      Location:63 → 176
      RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      84469593..84475884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49799.1 GenPept UniProtKB/Swiss-Prot:P49799

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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