Csrp2 cysteine and glycine-rich protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Csrp2provided by RGD
Official Full Name: cysteine and glycine-rich protein 2provided by RGD
Primary source: RGD:61950
See related: Ensembl:ENSRNOG00000003772 AllianceGenome:RGD:61950
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SmLIM
Summary: Predicted to enable actinin binding activity. Predicted to be a structural constituent of muscle. Involved in myoblast differentiation. Located in nucleus. Orthologous to human CSRP2 (cysteine and glycine rich protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 647.5), Thymus (RPKM 491.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (48235415..48254049)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (46349109..46367743)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (53630675..53649309)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results demonstrated that in undifferentiated olfactory precursor cells Csrp2 was distributed both in the nucleus and the cytoplasm, whereas CRIP2 was predominantly localized in the cytoplasm.
Title: Polyclonal antibodies to LIM proteins CRP2 and CRIP2 reveal their subcellular localizations in olfactory precursor cells.
TGFbeta activates ATF2 phosphorylation and Csrp2 gene expression via a CRE promoter element.
Title: Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2.
In rats, estrogen was found to up-regulate SmLIM genes in smooth muscle vascular cells.
Title: Caveolin-1, Id3a and two LIM protein genes are upregulated by estrogen in vascular smooth muscle cells.
CRP2 acted as a potent transcription coadaptor that remodeled silent cardiac myocyte chromatin and directed serum response factor-dependent smooth muscle gene activity.
Title: LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes.

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General gene information

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Markers

RH135193 (e-PCR)
- UniSTS:218470

D3S4161 (e-PCR)
- UniSTS:910

AW551867 (e-PCR)
- UniSTS:180118

RH129663 (e-PCR)
- UniSTS:212960

RH138817 (e-PCR)
- UniSTS:220904

RH141733 (e-PCR)
- UniSTS:223726

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actinin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of muscle	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
involved_in myoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cysteine and glycine-rich protein 2

Names: CRP2; LIM/double zinc-finger protein; cysteine-rich protein 2; smooth muscle cell LIM protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177425.3 → NP_803174.2 cysteine and glycine-rich protein 2

See identical proteins and their annotated locations for NP_803174.2

Status: VALIDATED

Source sequence(s)

CD373038, U44948

UniProtKB/Swiss-Prot

Q62908

UniProtKB/TrEMBL

A6IGF2

Related

ENSRNOP00000082765.1, ENSRNOT00000097951.1

Conserved Domains (2) summary

cd09480
Location:9 → 63

LIM1_CRP2; The first LIM domain of Cysteine Rich Protein 2 (CRP2)

cd09840
Location:119 → 172

LIM2_CRP2; The second LIM domain of Cysteine Rich Protein 2 (CRP2)