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    TRIM59 tripartite motif containing 59 [ Homo sapiens (human) ]

    Gene ID: 286827, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TRIM59provided by HGNC
    Official Full Name
    tripartite motif containing 59provided by HGNC
    Primary source
    HGNC:HGNC:30834
    See related
    Ensembl:ENSG00000213186 MIM:616148; AllianceGenome:HGNC:30834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRF1; TSBF1; IFT80L; RNF104; TRIM57
    Summary
    Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 4.6), lymph node (RPKM 4.6) and 21 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    3q25.33
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (160435503..160449786, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (163210117..163224400, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (160153291..160167574, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TRIM59-IFT80 readthrough (NMD candidate) Neighboring gene microRNA 16-2 Neighboring gene microRNA 15b Neighboring gene structural maintenance of chromosomes 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:160149190-160150389 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:160166710-160167230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20758 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:160167750-160168269 Neighboring gene beta-1,3-glucuronyltransferase 3 pseudogene 1 Neighboring gene RNA, U7 small nuclear 136 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TRIM59 is suppressed by androgen receptor and acts to promote lineage plasticity and treatment-induced neuroendocrine differentiation in prostate cancer. Fan L, et al. Oncogene, 2023 Feb. PMID 36544044
    2. TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells' killing. Feng X, et al. Invest New Drugs, 2022 Dec. PMID 36306030
    3. The role of Tripartite motif containing 59 (TRIM59) in the proliferation and prognosis of intrahepatic cholangiocarcinoma. Zhang JN, et al. Pathol Res Pract, 2022 Aug. PMID 35753134
    4. [Down-regulation of tripartite motif containing 59 (TRIM59) blocks the NF-κB signaling pathway and inhibits the invasion and migration of nasopharyngeal carcinoma cells]. Wang W, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2022 May. PMID 35603650
    5. Evaluation of tripartite motif 59 and its diagnostic utility in benign bowel diseases and colorectal cancer. Dahpy MA, et al. J Biochem Mol Toxicol, 2022 Jul. PMID 35377964

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM59 suppresses the brain ischaemia/reperfusion injury and pyroptosis of microglial through mediating the ubiquitination of NLRP3.
      Title: TRIM59 suppresses the brain ischaemia/reperfusion injury and pyroptosis of microglial through mediating the ubiquitination of NLRP3.
    2. A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification.
      Title: A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification.
    3. SLC35F2-SYVN1-TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53.
      Title: SLC35F2-SYVN1-TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53.
    4. TRIM59 is suppressed by androgen receptor and acts to promote lineage plasticity and treatment-induced neuroendocrine differentiation in prostate cancer.
      Title: TRIM59 is suppressed by androgen receptor and acts to promote lineage plasticity and treatment-induced neuroendocrine differentiation in prostate cancer.
    5. TRIM59 promotes steatosis and ferroptosis in non-alcoholic fatty liver disease via enhancing GPX4 ubiquitination.
      Title: TRIM59 promotes steatosis and ferroptosis in non-alcoholic fatty liver disease via enhancing GPX4 ubiquitination.
    6. TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells' killing.
      Title: TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells' killing.
    7. Regulations of LINC0196/miR-584-5p/miR-34a-5p/TRIM59 on Progression of Pediatric Neuroblastoma.
      Title: Regulations of LINC0196/miR-584-5p/miR-34a-5p/TRIM59 on Progression of Pediatric Neuroblastoma.
    8. The role of Tripartite motif containing 59 (TRIM59) in the proliferation and prognosis of intrahepatic cholangiocarcinoma.
      Title: The role of Tripartite motif containing 59 (TRIM59) in the proliferation and prognosis of intrahepatic cholangiocarcinoma.
    9. Evaluation of tripartite motif 59 and its diagnostic utility in benign bowel diseases and colorectal cancer.
      Title: Evaluation of tripartite motif 59 and its diagnostic utility in benign bowel diseases and colorectal cancer.
    10. [Down-regulation of tripartite motif containing 59 (TRIM59) blocks the NF-kappaB signaling pathway and inhibits the invasion and migration of nasopharyngeal carcinoma cells].
      Title: [Down-regulation of tripartite motif containing 59 (TRIM59) blocks the NF-κB signaling pathway and inhibits the invasion and migration of nasopharyngeal carcinoma cells].
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough TRIM59-IFT80

    Readthrough gene: TRIM59-IFT80, Included gene: IFT80

    Homology

    Clone Names

    • MGC26631, MGC129860, MGC129861

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 59
    Names
    RING finger protein 104
    tripartite motif-containing 57
    tumor suppressor TSBF-1
    tumor suppressor TSBF1
    NP_775107.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173084.3 → NP_775107.1  tripartite motif-containing protein 59

      See identical proteins and their annotated locations for NP_775107.1

      Status: VALIDATED

      Source sequence(s)
      AC024221, AI215011, AY159379, BC109260
      Consensus CDS
      CCDS3190.1
      UniProtKB/Swiss-Prot
      A8K5G9, D3DNL9, Q8IWR1
      Related
      ENSP00000311219.4, ENST00000309784.9
      Conserved Domains (2) summary
      pfam00643
      Location:96 → 134
      zf-B_box; B-box zinc finger
      cd16763
      Location:5 → 60
      RING-HC_TRIM59_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 59 (TRIM59) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      160435503..160449786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      163210117..163224400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IWR1.1 GenPept UniProtKB/Swiss-Prot:Q8IWR1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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