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    ppk25 pickpocket 25 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768722, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ppk25provided by FlyBase
    Official Full Name
    pickpocket 25provided by FlyBase
    Primary source
    FLYBASE:FBgn0053349
    Locus tag
    Dmel_CG33349
    See related
    AllianceGenome:FB:FBgn0053349
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15242; CG33349; Dmel\CG33349; llz; ppk-25; Ppk25; PPK25
    Summary
    Predicted to enable ligand-gated sodium channel activity. Involved in male courtship behavior and response to pheromone. Part of protein-containing complex. Is expressed in adult thoracic segment; adult ventral nerve cord; and neurons. Orthologous to human ASIC2 (acid sensing ion channel subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ppk25 in Genome Data Viewer
    Location:
    42E1-42E1; 2-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6950385..6952158)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2837890..2839663)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene missing-in-metastasis Neighboring gene transfer RNA:Lysine-CTT 1-9 Neighboring gene Chemosensory protein B 42c Neighboring gene Chemosensory protein B 42a Neighboring gene Cytochrome P450 6u1 Neighboring gene long non-coding RNA:CR44170 Neighboring gene UFM1 specific peptidase 1 Neighboring gene visceral mesodermal armadillo-repeats

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct Roles and Synergistic Function of Fru(M) Isoforms in Drosophila Olfactory Receptor Neurons. Zhang Y, et al. Cell Rep, 2020 Dec 15. PMID 33326795, Free PMC Article
    2. Amplification of Drosophila Olfactory Responses by a DEG/ENaC Channel. Ng R, et al. Neuron, 2019 Dec 4. PMID 31629603, Free PMC Article
    3. The receptor channel formed by ppk25, ppk29 and ppk23 can sense the Drosophila female pheromone 7,11-heptacosadiene. Liu T, et al. Genes Brain Behav, 2020 Feb. PMID 30345606
    4. Drosophila pheromone-sensing neurons expressing the ppk25 ion channel subunit stimulate male courtship and female receptivity. Vijayan V, et al. PLoS Genet, 2014 Mar. PMID 24675786, Free PMC Article
    5. Sexy DEG/ENaC channels involved in gustatory detection of fruit fly pheromones. Pikielny CW. Sci Signal, 2012 Nov 6. PMID 23131844

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. in olfactory receptor neurons PPK25 mediates Ca(2+)-dependent signal amplification via an intracellular calmodulin-binding motif
      Title: Amplification of Drosophila Olfactory Responses by a DEG/ENaC Channel.
    2. While ppk25 neurons are required for the responses to multiple pheromones, in both males and females these neurons are specifically involved in stimulating courtship and mating.
      Title: Drosophila pheromone-sensing neurons expressing the ppk25 ion channel subunit stimulate male courtship and female receptivity.
    3. This study indicated that two DEG/ENaC subunits, Nope and Ppk25, are coexpressed and have specific, nonredundant functions in a common subset of courtship-activating gustatory neurons in the wings and legs of males
      Title: Two Drosophila DEG/ENaC channel subunits have distinct functions in gustatory neurons that activate male courtship.
    4. These data show that ppk25 functions specifically in peripheral taste neurons involved in activation of courtship behavior.
      Title: A Drosophila DEG/ENaC subunit functions specifically in gustatory neurons required for male courtship behavior.
    5. Data show that when coexpressed, LLZ coprecipitated with CHEB42A, suggesting that the two proteins form a complex.
      Title: The Drosophila gene CheB42a is a novel modifier of Deg/ENaC channel function.
    6. ppk25 is necessary for response to female pheromones by D. melanogaster males
      Title: A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-activated cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated sodium channel activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in detection of pheromone IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_positive_effect male courtship behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to pheromone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pickpocket 25
    Names
    CG33349-PA
    lounge lizard
    ppk25-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6950385..6952158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206044.1 → NP_995766.1  pickpocket 25 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995766.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6S4
      Conserved Domains (1) summary
      pfam00858
      Location:18 → 432
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6S4 A1Z6S4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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