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    Stk36 serine/threonine kinase 36 [ Mus musculus (house mouse) ]

    Gene ID: 269209, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Stk36provided by MGI
    Official Full Name
    serine/threonine kinase 36provided by MGI
    Primary source
    MGI:MGI:1920831
    See related
    Ensembl:ENSMUSG00000033276 AllianceGenome:MGI:1920831
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FU; Fused; mKIAA1278; B930045J24; 1700112N14Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including cilium assembly; positive regulation of hh target transcription factor activity; and positive regulation of smoothened signaling pathway. Acts upstream of or within brain development and epithelial cilium movement involved in extracellular fluid movement. Located in cytoplasm. Is expressed in several structures, including central nervous system; sensory organ; skeleton; tail somite; and testis. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human STK36 (serine/threonine kinase 36). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 49.4), whole brain E14.5 (RPKM 6.3) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C4; 1 38.54 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74640583..74676053)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74601391..74636894)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E791 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene ring finger protein 25 Neighboring gene STARR-seq mESC enhancer starr_01341 Neighboring gene tubulin tyrosine ligase-like family, member 4 Neighboring gene cytochrome P450, family 27, subfamily a, polypeptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct. Nozawa YI, et al. Dev Dyn, 2013 Nov. PMID 23907739
    2. ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum. McCoy CJ, et al. Mol Biol Cell, 2023 Jun 1. PMID 36989043, Free PMC Article
    3. G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency. Chen M, et al. Am J Physiol Cell Physiol, 2009 Apr. PMID 19158402, Free PMC Article
    4. A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation. Maloveryan A, et al. J Cell Commun Signal, 2007 Dec. PMID 18600476, Free PMC Article
    5. Mammalian Fused is essential for sperm head shaping and periaxonemal structure formation during spermatogenesis. Nozawa YI, et al. Dev Biol, 2014 Apr 15. PMID 24525297, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum.
      Title: ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum.
    2. Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct.
      Title: Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct.
    3. Hydrocephalus and suppurative otitis media indicate dysfunction of motile cilia in Stk36 null mice
      Title: Congenital hydrocephalus in genetically engineered mice.
    4. mouse Fu is essential for construction of the central pair apparatus of motile, 9+2 cilia
      Title: Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.
    5. This growth inhibition is partially rescued by expression of ectopic Gli1, suggesting that Fu may contribute to enhance Hh signaling activity in cancer cells.
      Title: Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1278, MGC58023

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 36
    Names
    fused homolog
    serine/threonine kinase 36 (fused homolog, Drosophila)
    NP_001391006.1
    NP_001391007.1
    NP_778196.2
    XP_036021382.1
    XP_036021383.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404077.1 → NP_001391006.1  serine/threonine-protein kinase 36 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117610

    2. NM_001404078.1 → NP_001391007.1  serine/threonine-protein kinase 36 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117610
      Related
      ENSMUSP00000084433.5, ENSMUST00000087186.11

    3. NM_175031.4 → NP_778196.2  serine/threonine-protein kinase 36 isoform 1

      See identical proteins and their annotated locations for NP_778196.2

      Status: VALIDATED

      Source sequence(s)
      AC117610
      Consensus CDS
      CCDS35619.1
      UniProtKB/Swiss-Prot
      Q69ZM6, Q6PDI0, Q80XQ6
      Related
      ENSMUSP00000084430.5, ENSMUST00000087183.11
      Conserved Domains (2) summary
      smart00220
      Location:4 → 254
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14002
      Location:2 → 254
      STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

    RNA

    1. NR_175802.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117610

    2. NR_175803.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117610
      Related
      ENSMUST00000145673.8

    3. NR_175804.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117610

    4. NR_175805.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117610

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      74640583..74676053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165489.1 → XP_036021382.1  serine/threonine-protein kinase 36 isoform X2

      Conserved Domains (1) summary
      cd14002
      Location:2 → 254
      STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

    2. XM_036165490.1 → XP_036021383.1  serine/threonine-protein kinase 36 isoform X3

      Conserved Domains (4) summary
      COG1413
      Location:907 → 1152
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:962 → 989
      HEAT; HEAT repeat [structural motif]
      pfam13646
      Location:1028 → 1123
      HEAT_2; HEAT repeats
      cl21453
      Location:10 → 118
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZM6.3 GenPept UniProtKB/Swiss-Prot:Q69ZM6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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