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    Slc38a9 solute carrier family 38, member 9 [ Mus musculus (house mouse) ]

    Gene ID: 268706, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc38a9provided by MGI
    Official Full Name
    solute carrier family 38, member 9provided by MGI
    Primary source
    MGI:MGI:1918839
    See related
    Ensembl:ENSMUSG00000047789 AllianceGenome:MGI:1918839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A730092C09; 4833412L08Rik; 6720411P22Rik; 9130023D20Rik; 9430067K09Rik
    Summary
    Predicted to enable L-arginine transmembrane transporter activity and L-leucine transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport; cellular response to amino acid stimulus; and positive regulation of TOR signaling. Predicted to act upstream of or within amino acid transport. Predicted to be located in late endosome and lysosomal membrane. Predicted to be integral component of lysosomal membrane. Predicted to be part of Ragulator complex. Orthologous to human SLC38A9 (solute carrier family 38 member 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 7.7), thymus adult (RPKM 4.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 D2.2; 13 63.93 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (112792723..112875286)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (112656189..112738752)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene STARR-seq mESC enhancer starr_35695 Neighboring gene DEAD box helicase 4 Neighboring gene STARR-positive B cell enhancer ABC_E10817 Neighboring gene STARR-positive B cell enhancer ABC_E10818 Neighboring gene STARR-positive B cell enhancer ABC_E9889 Neighboring gene STARR-positive B cell enhancer mm9_chr13:113485543-113485843 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene Neighboring gene STARR-seq mESC enhancer starr_35698 Neighboring gene STARR-seq mESC enhancer starr_35701 Neighboring gene predicted gene, 41067 Neighboring gene STARR-seq mESC enhancer starr_35702 Neighboring gene phospholipid phosphatase 1 Neighboring gene Mtr4 exosome RNA helicase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The gene expression of the neuronal protein, SLC38A9, changes in mouse brain after in vivo starvation and high-fat diet. Hellsten SV, et al. PLoS One, 2017. PMID 28235079, Free PMC Article
    2. Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells. Wang D, et al. Biomolecules, 2021 Sep 6. PMID 34572527, Free PMC Article
    3. mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient. Wyant GA, et al. Cell, 2017 Oct 19. PMID 29053970, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells.
      Title: Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells.
    2. Study validates that SLC38A9 is an arginine sensor for the mTORC1 pathway, and we uncover an unexpectedly central role for SLC38A9 in amino acid homeostasis. SLC38A9 mediates the transport, in an arginine-regulated fashion, of many essential amino acids out of lysosomes, including leucine, which mTORC1 senses through the cytosolic Sestrin proteins.
      Title: mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.
    3. After high-fat diet, Slc38a9 was specifically upregulated in hypothalamus, while overall downregulation was noticed throughout the brain.
      Title: The gene expression of the neuronal protein, SLC38A9, changes in mouse brain after in vivo starvation and high-fat diet.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-asparagine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-glutamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-leucine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol sensor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in asparagine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of FNIP-folliculin RagC/D GAP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Ragulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neutral amino acid transporter 9
    Names
    putative sodium-coupled neutral amino acid transporter 9
    sodium-coupled neutral amino acid transporter 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178746.4 → NP_848861.1  neutral amino acid transporter 9

      See identical proteins and their annotated locations for NP_848861.1

      Status: VALIDATED

      Source sequence(s)
      AC159242, AK044735, BC052361
      Consensus CDS
      CCDS26775.1
      UniProtKB/Swiss-Prot
      Q80W70, Q8BGD6, Q8C5C3
      Related
      ENSMUSP00000052172.5, ENSMUST00000052514.6
      Conserved Domains (1) summary
      cl00456
      Location:114 → 556
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      112792723..112875286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247276.1 → XP_030103136.1  neutral amino acid transporter 9 isoform X1

      UniProtKB/Swiss-Prot
      Q80W70, Q8BGD6, Q8C5C3
      Conserved Domains (1) summary
      cl00456
      Location:114 → 556
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_006517670.4 → XP_006517733.1  neutral amino acid transporter 9 isoform X1

      See identical proteins and their annotated locations for XP_006517733.1

      UniProtKB/Swiss-Prot
      Q80W70, Q8BGD6, Q8C5C3
      Conserved Domains (1) summary
      cl00456
      Location:114 → 556
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_006517671.5 → XP_006517734.1  neutral amino acid transporter 9 isoform X2

      See identical proteins and their annotated locations for XP_006517734.1

      Conserved Domains (1) summary
      cl00456
      Location:107 → 549
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. XM_006517673.5 → XP_006517736.1  neutral amino acid transporter 9 isoform X3

      See identical proteins and their annotated locations for XP_006517736.1

      Conserved Domains (1) summary
      cl00456
      Location:52 → 494
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. XM_017315519.3 → XP_017171008.1  neutral amino acid transporter 9 isoform X3

      Conserved Domains (1) summary
      cl00456
      Location:52 → 494
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    6. XM_036158054.1 → XP_036013947.1  neutral amino acid transporter 9 isoform X4

      Conserved Domains (1) summary
      cl00456
      Location:37 → 289
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    7. XM_006517672.3 → XP_006517735.1  neutral amino acid transporter 9 isoform X2

      See identical proteins and their annotated locations for XP_006517735.1

      Conserved Domains (1) summary
      cl00456
      Location:107 → 549
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    8. XM_006517675.4 → XP_006517738.1  neutral amino acid transporter 9 isoform X3

      See identical proteins and their annotated locations for XP_006517738.1

      Conserved Domains (1) summary
      cl00456
      Location:52 → 494
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RNA

    1. XR_001780783.3 RNA Sequence

    2. XR_003950453.2 RNA Sequence

    3. XR_382737.5 RNA Sequence

    4. XR_873763.4 RNA Sequence

    5. XR_873764.4 RNA Sequence

    6. XR_873762.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175376.2: Suppressed sequence

      Description
      NM_175376.2: This RefSeq was permanently suppressed because it is primarily UTR sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGD6.1 GenPept UniProtKB/Swiss-Prot:Q8BGD6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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