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    vam6 putative guanyl-nucleotide exchange factor Vam6 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541859, updated on 13-Mar-2024

    Summary

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    Gene symbol
    vam6
    Gene description
    putative guanyl-nucleotide exchange factor Vam6
    Primary source
    PomBase:SPAC23H4.14
    Locus tag
    SPAC23H4.14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    vps39
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003424.3 (1582412..1585637, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative ribosome biogenesis protein Tsr1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene MRG family Clr6 histone deacetylase complex subunit Alp13 Neighboring gene centromere localized protein Cnl2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hepatic triglyceride lipase and lipoprotein lipase activities in post-heparin plasma of patients with various cancers. Masuno H, et al. Jpn J Cancer Res, 1985 Mar. PMID 2987072
    2. The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast. Valbuena N, et al. J Cell Sci, 2012 Apr 15. PMID 22344254, Free PMC Article
    3. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
    4. The genome sequence of Schizosaccharomyces pombe. Wood V, et al. Nature, 2002 Feb 21. PMID 11859360
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids.
      Title: The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TORC1 signaling EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in vacuole fusion EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in vacuole-mitochondria membrane tethering TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    part_of vacuolar HOPS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in vacuole-mitochondrion membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative guanyl-nucleotide exchange factor Vam6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1582412..1585637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018824.2 → NP_593392.1  putative guanyl-nucleotide exchange factor Vam6 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593392.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13955
      Conserved Domains (4) summary
      pfam00637
      Location:643 → 753
      Clathrin; Region in Clathrin and VPS
      pfam10366
      Location:492 → 602
      Vps39_1; Vacuolar sorting protein 39 domain 1
      pfam10367
      Location:785 → 893
      Vps39_2; Vacuolar sorting protein 39 domain 2
      cl02434
      Location:66 → 283
      CNH; CNH domain
    Nucleotide Protein
    Heading Accession and Version

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