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    ptr3 ubiquitin-activating enzyme E1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540744, updated on 7-Apr-2024

    Summary

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    Gene symbol
    ptr3
    Gene description
    ubiquitin-activating enzyme E1
    Locus tag
    SPBC1604.21c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPBC211.09; uba1
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (3888644..3892036)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene putative splicing factor 3B Neighboring gene gamma tubulin complex subunit Gfh1 Neighboring gene putative ubiquitin conjugating enzyme Ubc8 Neighboring gene exosome complex component mtr3 Neighboring gene miscRNA Neighboring gene putative Pet117 cytochrome c oxidase assemby protein Neighboring gene kinesin-like protein Tea2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for adenylation and thioester bond formation in the ubiquitin E1. Hann ZS, et al. Proc Natl Acad Sci U S A, 2019 Jul 30. PMID 31235585, Free PMC Article
    2. Isolation and molecular characterization of mRNA transport mutants in Schizosaccharomyces pombe. Azad AK, et al. Mol Biol Cell, 1997 May. PMID 9168469, Free PMC Article
    3. Domain alternation and active site remodeling are conserved structural features of ubiquitin E1. Lv Z, et al. J Biol Chem, 2017 Jul 21. PMID 28572513, Free PMC Article
    4. Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7. Hann ZS, et al. Acta Crystallogr F Struct Biol Commun, 2019 Aug 1. PMID 31397327, Free PMC Article
    5. Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity. Raychaudhuri S, et al. J Biol Chem, 2015 Jun 5. PMID 25918164, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These structures provide further insight into Ub E1 adenylation and thioester bond formation.
      Title: Structural basis for adenylation and thioester bond formation in the ubiquitin E1.
    2. Structure of S. pombe Uba1 in complex with Ubc15 reveals a new E1-E2 binding mode and a novel regulatory mechanism of ubiquitin E2 activity.
      Title: S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IC
    Inferred by Curator
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin activating enzyme activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ubiquitin activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin-activating enzyme E1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3888644..3892036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001355828.1 → NP_001342779.1  ubiquitin-activating enzyme E1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94609, Q9P7R2, Q9USY9
      Conserved Domains (1) summary
      TIGR01408
      Location:14 → 1011
      Ube1; ubiquitin-activating enzyme E1
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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