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    srb4 mediator complex subunit Srb4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540294, updated on 15-Mar-2024

    Summary

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    Gene symbol
    srb4
    Gene description
    mediator complex subunit Srb4
    Primary source
    PomBase:SPBC31F10.04c
    Locus tag
    SPBC31F10.04c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    med17
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (3757414..3759491, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene transcription factor TFIIH complex subunit Tfb2 Neighboring gene miscRNA Neighboring gene putative acyl-CoA thioesterase Neighboring gene putative ChaC-like cation transport regulator Neighboring gene protein mug37 Neighboring gene ADP-ribosylation factor Sar1 Neighboring gene putative protein lsb5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mammalian transcription activation domains of VP16, AP2 and CTF activate transcription in a whole cell extract from Schizosaccharomyces pombe through the SRB/mediator. Tamayo E, et al. Yeast, 2005 May. PMID 15942925
    2. The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator. Linder T, et al. J Biol Chem, 2004 Nov 19. PMID 15356001
    3. Structure of the Mediator head module. Larivière L, et al. Nature, 2012 Dec 20. PMID 23123849
    4. A chromatin-remodeling protein is a component of fission yeast mediator. Khorosjutina O, et al. J Biol Chem, 2010 Sep 24. PMID 20622008, Free PMC Article
    5. Cyclin C influences the timing of mitosis in fission yeast. Banyai G, et al. Mol Biol Cell, 2017 Jul 1. PMID 28515143, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings show that the activation of transcription by VP16, AP2 and CTF is through the mediator srb4, since depletion of Srb4 inhibits activated transcription but does not inhibit basal transcription
      Title: Mammalian transcription activation domains of VP16, AP2 and CTF activate transcription in a whole cell extract from Schizosaccharomyces pombe through the SRB/mediator.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription initiation by RNA polymerase II EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator complex subunit Srb4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3757414..3759491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022487.2 → NP_596566.1  mediator complex subunit Srb4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596566.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P87306
      Conserved Domains (1) summary
      pfam10156
      Location:8 → 452
      Med17; Subunit 17 of Mediator complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    5N9J_W.1
    5U0P_Q.1
    5U0S_Q.1

    Gene LinkOut

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